Umbilical cord and maternal blood red cell fatty acids and early childhood wheezing and eczema
Umbilical cord and maternal blood red cell fatty acids and early childhood wheezing and eczema
Background:
Few studies have explored whether fetal exposure to n-6 and n-3 fatty acids influences the inception of atopic disease.
Objective:
To assess prenatal fatty acid exposures as predictors of early childhood wheezing and eczema.
Methods:
In the Avon Longitudinal Study of Parents and Children, late pregnancy maternal blood samples and umbilical cord blood samples were assayed for n-6 and n-3 fatty acids (percentage of total red cell phospholipid), and mothers were asked about wheezing and eczema in their children. We measured associations of 11 n-6 and n-3 fatty acid exposures with wheezing at 30 to 42 months, with wheezing patterns defined by presence (+) or absence (?) of wheezing during 2 periods, 0 to 6 months and 30 to 42 months (transient infant, +/?; later-onset, ?/+; persistent, +/+; n = 1191 and n = 2764 for cord and maternal analyses, respectively), and with eczema at 18 to 30 months (n = 1238 and n = 2945 for cord and maternal analyses, respectively).
Results:
In cord blood red cells, the ratio of arachidonic:eicosapentaenoic acid was positively associated with eczema (adjusted odds ratio [OR] per doubling, 1.14; 95% CI, 1.00-1.31; P = .044), the ratio of linoleic acid:?-linolenic acid was positively associated with later-onset wheeze (OR, 1.30; CI, 1.04-1.61; P = .019), and the ratio of ?-linolenic acid:n-3 products was negatively associated with later-onset wheeze (OR, 0.86; CI, 0.75-0.99; P = .040). However, these associations were no longer significant after adjusting for multiple comparisons.
Conclusions:
It seems unlikely that fetal exposure to n-6 and n-3 fatty acids is an important determinant of early childhood wheezing and atopic disease.
n-3/n-6 fatty acids, wheezing, eczema, birth cohort, prenatal
531-537
Newson, R.B.
9c74a68e-2716-49cc-88bb-5f64312d6c13
Shaheen, S.O.
ae8e3194-c8a7-4f38-a71f-32da3ad0ea21
Henderson, A.J.
fed528f9-ccf9-4aca-85b8-e6d7da9cc8c3
Emmett, P.M.
77417a17-aee3-4890-b684-223020178051
Sherriff, A.
dcaabe89-808d-41f0-859e-ea36285d4150
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
2004
Newson, R.B.
9c74a68e-2716-49cc-88bb-5f64312d6c13
Shaheen, S.O.
ae8e3194-c8a7-4f38-a71f-32da3ad0ea21
Henderson, A.J.
fed528f9-ccf9-4aca-85b8-e6d7da9cc8c3
Emmett, P.M.
77417a17-aee3-4890-b684-223020178051
Sherriff, A.
dcaabe89-808d-41f0-859e-ea36285d4150
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Newson, R.B., Shaheen, S.O., Henderson, A.J., Emmett, P.M., Sherriff, A. and Calder, P.C.
(2004)
Umbilical cord and maternal blood red cell fatty acids and early childhood wheezing and eczema.
Journal of Allergy and Clinical Immunology, 114 (3), .
(doi:10.1016/j.jaci.2004.05.010).
Abstract
Background:
Few studies have explored whether fetal exposure to n-6 and n-3 fatty acids influences the inception of atopic disease.
Objective:
To assess prenatal fatty acid exposures as predictors of early childhood wheezing and eczema.
Methods:
In the Avon Longitudinal Study of Parents and Children, late pregnancy maternal blood samples and umbilical cord blood samples were assayed for n-6 and n-3 fatty acids (percentage of total red cell phospholipid), and mothers were asked about wheezing and eczema in their children. We measured associations of 11 n-6 and n-3 fatty acid exposures with wheezing at 30 to 42 months, with wheezing patterns defined by presence (+) or absence (?) of wheezing during 2 periods, 0 to 6 months and 30 to 42 months (transient infant, +/?; later-onset, ?/+; persistent, +/+; n = 1191 and n = 2764 for cord and maternal analyses, respectively), and with eczema at 18 to 30 months (n = 1238 and n = 2945 for cord and maternal analyses, respectively).
Results:
In cord blood red cells, the ratio of arachidonic:eicosapentaenoic acid was positively associated with eczema (adjusted odds ratio [OR] per doubling, 1.14; 95% CI, 1.00-1.31; P = .044), the ratio of linoleic acid:?-linolenic acid was positively associated with later-onset wheeze (OR, 1.30; CI, 1.04-1.61; P = .019), and the ratio of ?-linolenic acid:n-3 products was negatively associated with later-onset wheeze (OR, 0.86; CI, 0.75-0.99; P = .040). However, these associations were no longer significant after adjusting for multiple comparisons.
Conclusions:
It seems unlikely that fetal exposure to n-6 and n-3 fatty acids is an important determinant of early childhood wheezing and atopic disease.
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More information
Published date: 2004
Keywords:
n-3/n-6 fatty acids, wheezing, eczema, birth cohort, prenatal
Identifiers
Local EPrints ID: 25846
URI: http://eprints.soton.ac.uk/id/eprint/25846
ISSN: 0091-6749
PURE UUID: c12719cc-2f4d-4d56-b184-01ae7d5be6f8
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Date deposited: 11 Apr 2006
Last modified: 16 Mar 2024 02:51
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Contributors
Author:
R.B. Newson
Author:
S.O. Shaheen
Author:
A.J. Henderson
Author:
P.M. Emmett
Author:
A. Sherriff
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