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Effect of nutritional restriction in early pregnancy on isolated femoral artery function in mid-gestation fetal sheep

Nishina, Hidenori, Green, Lucy R., McGarrigle, Hugh H.G., Noakes, David E., Poston, Lucilla and Hanson, Mark A. (2003) Effect of nutritional restriction in early pregnancy on isolated femoral artery function in mid-gestation fetal sheep The Journal of Physiology, 553, (2), pp. 637-647. (doi:10.1113/jphysiol.2003.045278).

Record type: Article


Unbalanced maternal nutrition affects fetal endocrine and cardiovascular systems, sometimes accompanied by changes in growth, although this is usually in late gestation. We determined the effect of moderate restriction for the first half of gestation of maternal dietary protein, or of total calorific intake on isolated resistance artery function of mid-gestation fetal sheep. Welsh Mountain ewes were nutritionally restricted by 30 % of the recommended nutrient intake (globally restricted) or 30 % of the recommended protein intake (protein-restricted), compared to control ewes fed 100 % of recommended nutrient intake, for ~12 days prior to conception and for the subsequent 70 days of gestation. At mid-gestation, fetal and placental weights were similar in all dietary groups. In isolated femoral arteries, the response curve to noradrenaline was reduced in protein-restricted group fetuses (P < 0.05). Maximal relaxation (P < 0.01) and sensitivity (P < 0.05) to acetylcholine were markedly reduced in protein-restricted group fetuses, and to a smaller extent in globally restricted group fetuses (response curve, P < 0.05). The dilator response (P < 0.05) and sensitivity (P < 0.05) to the alpha2 agonist UK14304 was lower in protein-, but not in globally restricted group fetuses. The response (P < 0.05) and sensitivity (P < 0.05) to the nitric oxide donor sodium nitroprusside were reduced in protein-restricted group fetuses compared to controls. Our data show that dietary imbalance, in particular restricted protein, of the ewe can produce blunting of endothelial-dependent and -independent relaxation in systemic arteries from the mid-gestation fetus. These changes may precede perturbed late-gestation fetal and postnatal cardiovascular control.

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Published date: 2003
Organisations: Dev Origins of Health & Disease


Local EPrints ID: 25848
ISSN: 0022-3751
PURE UUID: 8a748527-7d46-4178-955a-8a8df6d89c26
ORCID for Lucy R. Green: ORCID iD

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Date deposited: 20 Apr 2006
Last modified: 17 Jul 2017 16:09

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Author: Hidenori Nishina
Author: Lucy R. Green ORCID iD
Author: Hugh H.G. McGarrigle
Author: David E. Noakes
Author: Lucilla Poston
Author: Mark A. Hanson

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