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A genetically engineered human Kunitz protease inhibitor with increased kallikrein inhibition in an ovine model of cardiopulmonary bypass

Ohri, S.K., Parratt, R., White, T., Becket, J., Brannan, J.J., Hunt, B.J. and Taylor, K.M. (2001) A genetically engineered human Kunitz protease inhibitor with increased kallikrein inhibition in an ovine model of cardiopulmonary bypass Perfusion, 16, (3), pp. 199-206.

Record type: Article

Abstract

recombinant human serine protease inhibitor known as Kunitz protease inhibitor (KPI) wild type has functional similarities to the bovine Kunitz inhibitor, aprotinin, and had shown a potential to reduce bleeding in an ovine model of cardiopulmonary bypass (CPB). The aim of this study was to assess KPI-185, a modification of KPI-wild type that differs from KPI-wild type in two amino acid residues and which enhances anti-kallikrein activity in a further double-blind, randomized study in an ovine model of CPB, and to compare with our previous study of KPI-wild type and aprotinin in the same ovine model. Post-operative drain losses and subjective assessment of wound 'dryness' showed no significant differences between KPI-185 and KPI-wild type, despite the significant enhancement of kallikrein inhibition using KPI-185 seen in serial kallikrein inhibition assays.
These preliminary findings support the hypothesis that kallikrein inhibition is not the major mechanism by which Kunitz inhibitors such as aprotinin reduce perioperative bleeding.

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Published date: 2001

Identifiers

Local EPrints ID: 25858
URI: http://eprints.soton.ac.uk/id/eprint/25858
ISSN: 0267-6591
PURE UUID: c64163ae-c9df-44f2-8c7e-32eb7cc0fd51

Catalogue record

Date deposited: 21 Apr 2006
Last modified: 17 Jul 2017 16:09

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Contributors

Author: S.K. Ohri
Author: R. Parratt
Author: T. White
Author: J. Becket
Author: J.J. Brannan
Author: B.J. Hunt
Author: K.M. Taylor

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