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Fetal programming of the neuroendocrine response to stress: links between low birth weight and the metabolic syndrome

Fetal programming of the neuroendocrine response to stress: links between low birth weight and the metabolic syndrome
Fetal programming of the neuroendocrine response to stress: links between low birth weight and the metabolic syndrome
There is now substantial agreement that small size at birth is associated with increased rates of the metabolic syndrome (glucose intolerance, high blood pressure, and dyslipidaemia) and related pathologies including cardiovascular disease in adult life. Evidence is also emerging that suggests programming of hormonal systems in response to an adverse fetal environment may be one of the mechanisms underlying these long-term consequences of early life events. In particular, alterations in the neuroendocrine response to stress may play an important part. Recent research suggests that increased adrenocortical and sympathoadrenal responses are associated with small size at birth. Evidence from epidemiological studies shows that subtle alterations in these neuroendocrine systems appear to exert a powerful influence on the levels of cardiovascular risk factors including plasma glucose and lipid concentrations and blood pressure.
birth weight, metabolic syndrome, stress fetal programming
0743-5800
819-826
Phillips, D.I.W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Phillips, D.I.W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6

Phillips, D.I.W. (2004) Fetal programming of the neuroendocrine response to stress: links between low birth weight and the metabolic syndrome. Endocrine Research, 30 (4), 819-826. (doi:10.1081/ERC-200044086).

Record type: Article

Abstract

There is now substantial agreement that small size at birth is associated with increased rates of the metabolic syndrome (glucose intolerance, high blood pressure, and dyslipidaemia) and related pathologies including cardiovascular disease in adult life. Evidence is also emerging that suggests programming of hormonal systems in response to an adverse fetal environment may be one of the mechanisms underlying these long-term consequences of early life events. In particular, alterations in the neuroendocrine response to stress may play an important part. Recent research suggests that increased adrenocortical and sympathoadrenal responses are associated with small size at birth. Evidence from epidemiological studies shows that subtle alterations in these neuroendocrine systems appear to exert a powerful influence on the levels of cardiovascular risk factors including plasma glucose and lipid concentrations and blood pressure.

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Published date: 2004
Keywords: birth weight, metabolic syndrome, stress fetal programming

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Local EPrints ID: 25904
URI: http://eprints.soton.ac.uk/id/eprint/25904
ISSN: 0743-5800
PURE UUID: 2a8d2834-3002-4734-9df3-1584742923fd

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Date deposited: 21 Apr 2006
Last modified: 15 Mar 2024 07:06

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Author: D.I.W. Phillips

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