The University of Southampton
University of Southampton Institutional Repository

Maternal body composition, offspring blood pressure and the hypothalamic-pituitary-adrenal axis

Phillips, D.I.W., Bennett, F.I., Wilks, R., Thame, M., Boyne, M., Osmond, C. and Forrester, T.E. (2005) Maternal body composition, offspring blood pressure and the hypothalamic-pituitary-adrenal axis Paediatric and Perinatal Epidemiology, 19, (4), pp. 294-302. (doi:10.1111/j.1365-3016.2005.00661.x).

Record type: Article

Abstract

We tested the hypothesis that women who are thin or have poor pregnancy weight gain have offspring with higher blood pressure and examined whether this link is mediated by increased secretion of cortisol. We studied a cohort of 388 children born in Kingston, Jamaica. From hospital records we obtained information about their mother's body mass index (BMI) and weight gain during pregnancy. At age 8.5 years we measured the children's fasting plasma cortisol concentrations and blood pressure and assessed their mother's anthropometry. There were no relationships between the mother's BMI or weight gain during pregnancy and offspring blood pressure. However, mothers with a greater subscapular to triceps skinfold thickness ratio (SSTR) had offspring with higher blood pressure (5.6 mmHg systolic and 3.7 mmHg diastolic increase per unit change in SSTR, P = 0.002 and P = 0.008 respectively). Fasting plasma cortisol concentrations correlated with the children's systolic (r = 0.33, P < 0.0001) and diastolic pressures (r = 0.12, P = 0.02) independently of age, gender, weight or socio-economic status and were also predicted by the mother's SSTR. These findings suggest that maternal truncal obesity rather than thinness is associated with raised blood pressure in the offspring, and that this link may be mediated by increased cortisol secretion.

Full text not available from this repository.

More information

Published date: 2005

Identifiers

Local EPrints ID: 25906
URI: http://eprints.soton.ac.uk/id/eprint/25906
ISSN: 0269-5022
PURE UUID: 123d6eb6-177d-45c8-991f-004469f1967f
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 12 Apr 2006
Last modified: 17 Jul 2017 16:09

Export record

Altmetrics

Contributors

Author: D.I.W. Phillips
Author: F.I. Bennett
Author: R. Wilks
Author: M. Thame
Author: M. Boyne
Author: C. Osmond ORCID iD
Author: T.E. Forrester

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×