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Enzymatic Computing

Enzymatic Computing
Enzymatic Computing
The conformational dynamics of enzymes is a computational resource that fuses milieu signals in a nonlinear fashion. Response surface methodology can be used to elicit computational functionality from enzyme dynamics. We constructed a tabletop prototype to implement enzymatic signal processing in a device context and employed it in conjunction with malate dehydrogenase to perform the linearly inseparable exclusive-or operation. This shows that proteins can execute signal processing operations that are more complex than those performed by individual threshold elements. We view the experiments reported, though restricted to the two-variable case, as a stepping stone to computational networks that utilize the precise reproducibility of proteins, and the concomitant reproducibility of their nonlinear dynamics, to implement complex pattern transformations.
Molecular Computing, conformation-based computing, malate dehydrogenase, enzyme kinetics, nanotechnology
553-559
Zauner, K.-P.
c8b22dbd-10e6-43d8-813b-0766f985cc97
Conrad, M.
5b4c1f50-0b05-4e39-abc5-8cab4e408ac8
Zauner, K.-P.
c8b22dbd-10e6-43d8-813b-0766f985cc97
Conrad, M.
5b4c1f50-0b05-4e39-abc5-8cab4e408ac8

Zauner, K.-P. and Conrad, M. (2001) Enzymatic Computing. Biotechnology Progress, 17 (3), 553-559.

Record type: Article

Abstract

The conformational dynamics of enzymes is a computational resource that fuses milieu signals in a nonlinear fashion. Response surface methodology can be used to elicit computational functionality from enzyme dynamics. We constructed a tabletop prototype to implement enzymatic signal processing in a device context and employed it in conjunction with malate dehydrogenase to perform the linearly inseparable exclusive-or operation. This shows that proteins can execute signal processing operations that are more complex than those performed by individual threshold elements. We view the experiments reported, though restricted to the two-variable case, as a stepping stone to computational networks that utilize the precise reproducibility of proteins, and the concomitant reproducibility of their nonlinear dynamics, to implement complex pattern transformations.

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Published date: 2001
Keywords: Molecular Computing, conformation-based computing, malate dehydrogenase, enzyme kinetics, nanotechnology
Organisations: Agents, Interactions & Complexity

Identifiers

Local EPrints ID: 259138
URI: http://eprints.soton.ac.uk/id/eprint/259138
PURE UUID: 2796d904-a03c-419f-8649-dc1a7b1027b5

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Date deposited: 12 Mar 2004
Last modified: 14 Mar 2024 06:20

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Contributors

Author: K.-P. Zauner
Author: M. Conrad

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