The effect of birth weight on glucose tolerance in pigs at 3 and 12 months of age
The effect of birth weight on glucose tolerance in pigs at 3 and 12 months of age
Aims/hypothesis: the aim of this study was to examine the effect of birth weight on glucose tolerance in juvenile and adult pigs.
Methods: low (<1.47 kg) and high (>1.53 kg) birth weight piglets from 15 litters were studied at 3 (n=47) and 12 (n=17) months of age. At each age, selected pigs were tranquilised and catheters were inserted into the dorsal aorta and caudal vena cava under general anaesthesia. After recovery, glucose (0.5 g/kg; i.v.) was administered and regular arterial blood samples were taken for 2 h for plasma glucose and insulin measurements. Hepatic gluconeogenic enzyme activities were measured at post mortem.
Results: at 12, but not at 3 months of age, the area under the glucose and insulin curves after glucose administration were greater (p<0.05) in low rather than in high birth weight pigs. The glucose area at 12 months was negatively correlated with body weight and BMI at birth. Disproportionate shape at birth was associated with reduced hepatic gluconeogenic enzyme concentrations and low birth weight pigs had reduced basal glucose concentrations at 12 months of age.
Conclusion/interpretation: this study has shown an association between low birth weight and thinness at birth and glucose intolerance at 12 months of postnatal age, but not at 3 months. This effect was not due to insulin deficiency or increased hepatic gluconeogenic enzyme activity.
intra-uterine programming, low birth weight, glucose tolerance, pigs
1247-1254
Poore, K.
b9529ba3-6432-4935-b8fd-6e382f11f0ad
Fowden, A.
4784e591-9513-494d-b407-4d4357121bf6
2002
Poore, K.
b9529ba3-6432-4935-b8fd-6e382f11f0ad
Fowden, A.
4784e591-9513-494d-b407-4d4357121bf6
Poore, K. and Fowden, A.
(2002)
The effect of birth weight on glucose tolerance in pigs at 3 and 12 months of age.
Diabetologia, 45 (9), .
(doi:10.1007/s00125-002-0849-y).
Abstract
Aims/hypothesis: the aim of this study was to examine the effect of birth weight on glucose tolerance in juvenile and adult pigs.
Methods: low (<1.47 kg) and high (>1.53 kg) birth weight piglets from 15 litters were studied at 3 (n=47) and 12 (n=17) months of age. At each age, selected pigs were tranquilised and catheters were inserted into the dorsal aorta and caudal vena cava under general anaesthesia. After recovery, glucose (0.5 g/kg; i.v.) was administered and regular arterial blood samples were taken for 2 h for plasma glucose and insulin measurements. Hepatic gluconeogenic enzyme activities were measured at post mortem.
Results: at 12, but not at 3 months of age, the area under the glucose and insulin curves after glucose administration were greater (p<0.05) in low rather than in high birth weight pigs. The glucose area at 12 months was negatively correlated with body weight and BMI at birth. Disproportionate shape at birth was associated with reduced hepatic gluconeogenic enzyme concentrations and low birth weight pigs had reduced basal glucose concentrations at 12 months of age.
Conclusion/interpretation: this study has shown an association between low birth weight and thinness at birth and glucose intolerance at 12 months of postnatal age, but not at 3 months. This effect was not due to insulin deficiency or increased hepatic gluconeogenic enzyme activity.
This record has no associated files available for download.
More information
Published date: 2002
Keywords:
intra-uterine programming, low birth weight, glucose tolerance, pigs
Identifiers
Local EPrints ID: 25914
URI: http://eprints.soton.ac.uk/id/eprint/25914
ISSN: 0012-186X
PURE UUID: a3d796b6-ec99-4f36-8707-8b88b1ca23d9
Catalogue record
Date deposited: 11 Apr 2006
Last modified: 16 Mar 2024 03:29
Export record
Altmetrics
Contributors
Author:
A. Fowden
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics