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The effects of birth weight on basal cardiovascular function in pigs at 3 months of age

Poore, K.R., Forhead, A.J., Gardner, D.S., Giussani, D.A. and Fowden, A.L. (2002) The effects of birth weight on basal cardiovascular function in pigs at 3 months of age The Journal of Physiology, 539, (3), pp. 969-978. (doi:10.1113/jphysiol.2001.012926).

Record type: Article

Abstract

In man, epidemiological studies have shown that low birth weight (BW) is associated with an increased risk of cardiovascular disease in later life. In this study, the long-term consequences of variations in natural BW on basal cardiovascular function were investigated in pigs at 3 months of postnatal age. Low (< 1.41 kg; n = 20) and high (> 1.52 kg; n = 20) BW Large White piglets were selected from a total of 12 litters for study at 3 months of age. Basal mean arterial pressure (MAP) and heart rate (HR) were recorded for ~30 min using standard recording equipment and basal arterial blood samples were taken for hormone analyses. Concentrations of angiotensin-converting enzyme (ACE) were also measured in kidney, lung and plasma. Basal MAP, but not HR, in 3-month-old pigs was significantly inversely related to BW and positively related to the ratio of head length to BW. Postnatal growth rate of low BW pigs was slower than that of high BW pigs such that low BW piglets remained significantly smaller at 3 months of age. There were no differences in basal plasma adrenaline or cortisol concentrations between low and high BW pigs. However, basal plasma noradrenaline concentrations were significantly elevated in low BW compared to high BW pigs. Renal and pulmonary ACE levels were significantly reduced in low BW compared to high BW pigs. These data show that basal MAP in 3-month-old pigs is negatively associated with BW and positively correlated to disproportionate size at birth. This effect was associated with an increase in basal plasma noradrenaline concentrations.

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More information

Published date: 2002
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 25915
URI: http://eprints.soton.ac.uk/id/eprint/25915
ISSN: 0022-3751
PURE UUID: 60d84898-74e1-4ee9-aa7c-ef80bf7759b6
ORCID for K.R. Poore: ORCID iD orcid.org/0000-0002-1455-0615

Catalogue record

Date deposited: 11 Apr 2006
Last modified: 17 Jul 2017 16:09

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Contributors

Author: K.R. Poore ORCID iD
Author: A.J. Forhead
Author: D.S. Gardner
Author: D.A. Giussani
Author: A.L. Fowden

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