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Undernutrition during the first half of gestation increases the predominance of fetal tissue in late-gestation ovine placentomes

Steyn, Clare, Hawkins, Paul, Saito, Tsukuru, Noakes, David E., Kingdom, John C. and Hanson, Mark A. (2001) Undernutrition during the first half of gestation increases the predominance of fetal tissue in late-gestation ovine placentomes European Journal of Obstetrics, Gynecology and Reproductive Biology, 98, (2), pp. 165-170. (doi:10.1016/S0301-2115(01)00321-9).

Record type: Article


Objective: To investigate, in sheep, the effects of maternal undernutrition during the first half of pregnancy on placental growth and development and fetal growth.
Study design: Six ewes (R) were subjected to a 15% reduction in nutrient intake for the first 70 days of gestation and thereafter received the recommended daily intake. Another group of six ewes (C) received the recommended daily intake throughout pregnancy. At 130 days gestation the ewes were killed and morphological and morphometrical measurements were carried out on the placenta and fetus.
Results: Undernutrition resulted in a significant alteration in placental morphology, which was seen as increased growth of the fetal side of the placenta in R animals. However, fetal size in late gestation was not affected by the undernutrition, suggesting that placental adaptation was successful in maintaining fetal growth.
Conclusion: Placental adaptations, including changes in gross morphology, may preserve fetal growth if maternal undernutrition is not severe. The mechanisms remain to be elucidated.

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Published date: 2001
Keywords: undernutrition, fetus, placenta


Local EPrints ID: 25994
ISSN: 0301-2115
PURE UUID: 411bef4d-c711-478c-b6c3-aab02db08592

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Date deposited: 24 Apr 2006
Last modified: 17 Jul 2017 16:08

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Author: Clare Steyn
Author: Paul Hawkins
Author: Tsukuru Saito
Author: David E. Noakes
Author: John C. Kingdom
Author: Mark A. Hanson

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