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Birth weight, infant weight gain, and cause-specific mortality: the Hertfordshire Cohort Study

Record type: Article

Low birth weight, a marker of adverse intrauterine circumstances, is known to be associated with a range of disease outcomes in later life, including coronary heart disease, hypertension, type 2 diabetes, and osteoporosis. However, it may also decrease the risk of other common conditions, most notably neoplastic disease. The authors describe the associations between birth weight, infant weight gain, and a range of mortality outcomes in the Hertfordshire Cohort. This study included 37,615 men and women born in Hertfordshire, United Kingdom, in 1911–1939; 7,916 had died by the end of 1999. For men, lower birth weight was associated with increased risk of mortality from circulatory disease (hazard ratio per standard deviation decrease in birth weight = 1.08, 95% confidence interval: 1.04, 1.11) and from accidental falls but with decreased risk of mortality from cancer (hazard ratio per standard deviation decrease in birth weight = 0.94, 95% confidence interval: 0.90, 0.98). For women, lower birth weight was associated with a significantly (p < 0.05) increased risk of mortality from circulatory and musculoskeletal disease, pneumonia, injury, and diabetes. Overall, a one-standard-deviation increase in birth weight reduced all-cause mortality risk by age 75 years by 0.86% for both men and women.

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Citation

Syddall, H.E., Aihie-Sayer, A., Simmonds, S.J., Osmond, C., Cox, V., Dennison, E.M., Barker, D.J.P. and Cooper, C. (2005) Birth weight, infant weight gain, and cause-specific mortality: the Hertfordshire Cohort Study American Journal of Epidemiology, 161, (11), pp. 1074-1080. (doi:10.1093/aje/kwi137).

More information

Published date: 2005
Keywords: birth weight, cohort studies, infant, mortality, risk, weight gain

Identifiers

Local EPrints ID: 26009
URI: http://eprints.soton.ac.uk/id/eprint/26009
ISSN: 0002-9262
PURE UUID: 0beba542-8b86-4744-b8df-c8b4af1a7590
ORCID for H.E. Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 12 Apr 2006
Last modified: 17 Jul 2017 16:08

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Contributors

Author: H.E. Syddall ORCID iD
Author: A. Aihie-Sayer
Author: S.J. Simmonds
Author: C. Osmond ORCID iD
Author: V. Cox
Author: E.M. Dennison
Author: D.J.P. Barker
Author: C. Cooper

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