The University of Southampton
University of Southampton Institutional Repository

Leukodepletion reduces renal injury in coronary revascularization: a prospective randomized study

Tang, Augustine T.M., Alexiou, Christos, Hsu, Jeff, Sheppard, Stuart V., Haw, Marcus P. and Ohri, Sunil K. (2002) Leukodepletion reduces renal injury in coronary revascularization: a prospective randomized study The Annals of Thoracic Surgery, 74, (2), pp. 372-377. (doi:10.1016/S0003-4975(02)03715-3).

Record type: Article


Background: cardiopulmonary bypass (CPB) is an important contributor to renal failure, which is a well-recognized complication after coronary artery bypass grafting (CABG). Leukodepletion reduces CPB-associated inflammation and resultant end-organ injuries. However, its effectiveness in renal protection has not been evaluated in a prospective randomized clinical setting.
Methods: forty low-risk patients awaiting elective CABG with normal preoperative cardiac and renal function were prospectively randomized into those undergoing nonpulsatile CPB without (group A: N = 20) and with leukodepletion (group B: N = 20). Renal glomerular and tubular injury were assessed by urinary excretion of microalbumin and retinol binding protein (RBP) indexed to creatinine (Cr), respectively. Daily measurements were taken from admission to postoperative day 5. Fluid balance, serum creatinine, and blood urea were also monitored.
Results: no mortality or renal complication occurred. Both groups had similar demographic makeups, Parsonnet scores, extents of coronary revascularization and, durations of CPB and aortic cross-clamping. Daily fluid balance, serum creatinine, and blood urea remained comparable in both groups throughout the study period. From equal preoperative values, a significantly higher release of urinary RBP:Cr (7,807 ± 2,227 vs 3,942 ± 2,528; p < 0.001) and urinary microalbumin:Cr (59.4 ± 38.0 vs 4.7 ± 6.7; p < 0.0001) occurred in group A, peaking on day 1 before returning to approximate baseline levels.
Conclusions: although clinically overt renal complications were absent, sensitive indicators revealed significantly more injury to both renal tubules and glomeruli after nonpulsatile CPB without leukodepletion. These data suggest that leukocytes play an important role in post-CPB renal dysfunction, and leukodepletion may offer some renal protection in low-risk patients during CABG.

Full text not available from this repository.

More information

Published date: August 2002


Local EPrints ID: 26014
ISSN: 0003-4975
PURE UUID: 7968c63a-057f-4349-84b5-7aabc6c8387f

Catalogue record

Date deposited: 20 Apr 2006
Last modified: 17 Jul 2017 16:08

Export record



Author: Augustine T.M. Tang
Author: Christos Alexiou
Author: Jeff Hsu
Author: Stuart V. Sheppard
Author: Marcus P. Haw
Author: Sunil K. Ohri

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.