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Birth weight and the risk of depressive disorder in late life

Birth weight and the risk of depressive disorder in late life
Birth weight and the risk of depressive disorder in late life
Background: Low birth weight is a risk factor for coronary heart disease, diabetes, stroke and hypertension. Depression is highly associated with these conditions.
Aims: To examine the association between birth weight and depression in late life.
Method: A total of 882 singleton term births in the 1920s had contemporary records of birth weight and weight at 1 year. At 68 years all completed the Geriatric Depression Scale and 867 completed the Geriatric Mental State Examination. A logistic regression was used to analyse the associations between depression, birth weight and weight at 1 year while adjusting for known risk factors.
Results: Current social class, social class at birth, recent bereavement, social isolation and physical illness increased the risk of depression. After adjusting for these and weight at 1 year, the odds ratios for depression among men, but not women, rose incrementally with decreasing birth weight (1.0, 12.8; for continuous variable, P<0.007).
Conclusions: Foetal undernutrition predisposes men to depression in late adult life. If replicated, these results would suggest a neurodevelopmental aetiology of depression, possibly mediated by programming of the hypothalamic—pituitary—adrenal axis.
0007-1250
450-455
Thompson, Christopher
f05318d5-9161-4fb8-8846-afe0407aa5bd
Syddall, Holly
a0181a93-8fc3-4998-a996-7963f0128328
Rodin, Ian
f8c4af02-d415-45a1-9d91-45c3af5a204f
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243
Thompson, Christopher
f05318d5-9161-4fb8-8846-afe0407aa5bd
Syddall, Holly
a0181a93-8fc3-4998-a996-7963f0128328
Rodin, Ian
f8c4af02-d415-45a1-9d91-45c3af5a204f
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243

Thompson, Christopher, Syddall, Holly, Rodin, Ian, Osmond, Clive and Barker, David J.P. (2001) Birth weight and the risk of depressive disorder in late life. British Journal of Psychiatry, 179, 450-455.

Record type: Article

Abstract

Background: Low birth weight is a risk factor for coronary heart disease, diabetes, stroke and hypertension. Depression is highly associated with these conditions.
Aims: To examine the association between birth weight and depression in late life.
Method: A total of 882 singleton term births in the 1920s had contemporary records of birth weight and weight at 1 year. At 68 years all completed the Geriatric Depression Scale and 867 completed the Geriatric Mental State Examination. A logistic regression was used to analyse the associations between depression, birth weight and weight at 1 year while adjusting for known risk factors.
Results: Current social class, social class at birth, recent bereavement, social isolation and physical illness increased the risk of depression. After adjusting for these and weight at 1 year, the odds ratios for depression among men, but not women, rose incrementally with decreasing birth weight (1.0, 12.8; for continuous variable, P<0.007).
Conclusions: Foetal undernutrition predisposes men to depression in late adult life. If replicated, these results would suggest a neurodevelopmental aetiology of depression, possibly mediated by programming of the hypothalamic—pituitary—adrenal axis.

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More information

Published date: 2001

Identifiers

Local EPrints ID: 26031
URI: http://eprints.soton.ac.uk/id/eprint/26031
ISSN: 0007-1250
PURE UUID: 9dce75f1-6694-4d4d-a002-348fb99a9ebf
ORCID for Holly Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 21 Apr 2006
Last modified: 10 Jan 2022 02:41

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Contributors

Author: Christopher Thompson
Author: Holly Syddall ORCID iD
Author: Ian Rodin
Author: Clive Osmond ORCID iD
Author: David J.P. Barker

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