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Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspring

Torrens, Christopher, Brawley, Lee, Barker, Alison C., Itoh, Shigeru, Poston, Lucilla and Hanson, Mark A. (2003) Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspring The Journal of Physiology, 547, (Pt 1), pp. 77-84. (doi:10.1113/jphysiol.2002.026120).

Record type: Article


Dietary protein restriction during gestation has been shown to produce vascular dysfunction in pregnant rats and hypertension in their offspring. However, no studies have to date examined the effects of such 'programming' on the vascular function of female offspring when they in turn become pregnant. We have therefore studied isolated conduit and resistance artery function from pregnant female offspring of control (C, 18 % casein) and protein-restricted (PR, 9 % casein) pregnant dams. There were no differences in birth weight, weight gain during pregnancy, litter size, fetal weight, placental weight, fetal : placental weight ratio or organ weights between the C and PR groups. In isolated mesenteric arteries, the vasodilatation in response to the endothelial-dependent vasodilator acetylcholine (ACh) and the -adrenoceptor agonist isoprenaline was decreased in the PR group, while there were no differences in the constriction in response to potassium (125 mM) or the 1-adrenoceptor agonist phenylephrine (PE). No differences in any responses were seen in the isolated thoracic aorta. We conclude that dietary protein restriction in pregnancy programmes vasodilator dysfunction in isolated resistance arteries of female offspring when they become pregnant, but does not affect conduit arteries.

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Published date: 15 February 2003
Organisations: Dev Origins of Health & Disease


Local EPrints ID: 26039
ISSN: 0022-3751
PURE UUID: 664b6b72-7d59-41ab-978c-c9c21354df6f

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Date deposited: 21 Apr 2006
Last modified: 17 Jul 2017 16:08

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Author: Lee Brawley
Author: Alison C. Barker
Author: Shigeru Itoh
Author: Lucilla Poston
Author: Mark A. Hanson

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