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Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans

Tricon, S., Burdge, G.C., Kew, S., Banerjee, T., Russell, J.J., Jones, E.L., Grimble, R.F., Williams, C.M., Yaqoob, P. and Calder, P.C. (2004) Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans American Journal of Clinical Nutrition, 80, (3), pp. 614-620.

Record type: Article

Abstract

Background: Conjugated linoleic acid (CLA) is reported to have weight-reducing and antiatherogenic properties when fed to laboratory animals. However, the effects of CLA on human health and, in particular, the effects of individual CLA isomers are unclear.
Objective: This study investigated the effects of 3 doses of highly enriched cis-9,trans-11 (0.59, 1.19, and 2.38 g/d) or trans-10,cis-12 (0.63, 1.26, and 2.52 g/d) CLA preparations on body composition, blood lipid profile, and markers of insulin resistance in healthy men.
Design: Healthy men consumed 1, 2, and 4 capsules sequentially, containing either 80% cis-9,trans-11 CLA or 80% trans-10,cis-12 CLA for consecutive 8-wk periods. This phase was followed by a 6-wk washout and a crossover to the other isomer.
Results: Body composition was not significantly affected by either isomer of CLA. Mean plasma triacylglycerol concentration was higher during supplementation with trans-10,cis-12 CLA than during that with cis-9,trans-11 CLA, although there was no influence of dose. There were significant effects of both isomer and dose on plasma total cholesterol and LDL-cholesterol concentrations but not on HDL-cholesterol concentration. The ratios of LDL to HDL cholesterol and of total to HDL cholesterol were higher during supplementation with trans-10,cis-12 CLA than during that with cis-9,trans-11 CLA. CLA supplementation had no significant effect on plasma insulin concentration, homeostasis model for insulin resistance, or revised quantitative insulin sensitivity check index.
Conclusion: Divergent effects of cis-9,trans-11 CLA and trans-10,cis-12 CLA appear on the blood lipid profile in healthy humans: trans-10,cis-12 CLA increases LDL:HDL cholesterol and total:HDL cholesterol, whereas cis-9,trans-11 CLA decreases them.

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More information

Published date: September 2004
Additional Information: Original research communication
Keywords: cholesterol, conjugated linoleic acid, high-density lipoprotein, low-density lipoprotein, triacylglycerol

Identifiers

Local EPrints ID: 26048
URI: http://eprints.soton.ac.uk/id/eprint/26048
ISSN: 0002-9165
PURE UUID: 5c552f37-6936-47cc-bfaa-242364553e74
ORCID for G.C. Burdge: ORCID iD orcid.org/0000-0002-7665-2967

Catalogue record

Date deposited: 12 Apr 2006
Last modified: 17 Jul 2017 16:08

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Contributors

Author: S. Tricon
Author: G.C. Burdge ORCID iD
Author: S. Kew
Author: T. Banerjee
Author: J.J. Russell
Author: E.L. Jones
Author: R.F. Grimble
Author: C.M. Williams
Author: P. Yaqoob
Author: P.C. Calder

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