Central hypothalamic-pituitary-adrenal activity and the metabolic syndrome: studies using the corticotrophin-releasing hormone test
Central hypothalamic-pituitary-adrenal activity and the metabolic syndrome: studies using the corticotrophin-releasing hormone test
A number of studies have suggested that the metabolic syndrome (principally, the combination of hypertension, glucose intolerance, and dyslipidemia) is associated with subtle dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis leading to raised circulating cortisol concentrations. The mechanisms underlying these observations are not known. We assessed the salivary cortisol response to awakening and pituitary-adrenal responses during a 100-?g human corticotrophin-releasing hormone (CRH) test and a dexamethasone-suppressed CRH test in a well-characterized group of 65-year-old men (n = 122). In the cohort from which this subgroup was drawn, there were associations between the components of the metabolic syndrome and 9AM cortisol concentration in line with previous studies. However, there were no significant associations between blood pressure, glucose tolerance, and lipid concentrations and the dynamic tests of HPA activity. We therefore found no evidence to suggest that exaggerated pituitary responsiveness or increased central drive to the pituitary, as determined by CRH testing, plays a part in the development of the metabolic syndrome.
hydrocortisone, diagnosis, non-u.s.gov't, statistics, etiology, risk factors, activity, u.s.gov't, saliva, antagonists & inhibitors, obesity, pharmacology, aged, male, cohort studies, nonparametric
720-726
Ward, Alexandra M.V.
d137a1e8-4c10-48c6-b366-07d2934fcd24
Syddall, Holly E.
a0181a93-8fc3-4998-a996-7963f0128328
Wood, Peter J.
30039979-9541-4a0a-8aef-0dfe53114e02
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Phillips, David I.W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
2004
Ward, Alexandra M.V.
d137a1e8-4c10-48c6-b366-07d2934fcd24
Syddall, Holly E.
a0181a93-8fc3-4998-a996-7963f0128328
Wood, Peter J.
30039979-9541-4a0a-8aef-0dfe53114e02
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Phillips, David I.W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Ward, Alexandra M.V., Syddall, Holly E., Wood, Peter J., Dennison, Elaine M. and Phillips, David I.W.
(2004)
Central hypothalamic-pituitary-adrenal activity and the metabolic syndrome: studies using the corticotrophin-releasing hormone test.
Metabolism, 53 (6), .
(doi:10.1016/j.metabol.2004.01.008).
Abstract
A number of studies have suggested that the metabolic syndrome (principally, the combination of hypertension, glucose intolerance, and dyslipidemia) is associated with subtle dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis leading to raised circulating cortisol concentrations. The mechanisms underlying these observations are not known. We assessed the salivary cortisol response to awakening and pituitary-adrenal responses during a 100-?g human corticotrophin-releasing hormone (CRH) test and a dexamethasone-suppressed CRH test in a well-characterized group of 65-year-old men (n = 122). In the cohort from which this subgroup was drawn, there were associations between the components of the metabolic syndrome and 9AM cortisol concentration in line with previous studies. However, there were no significant associations between blood pressure, glucose tolerance, and lipid concentrations and the dynamic tests of HPA activity. We therefore found no evidence to suggest that exaggerated pituitary responsiveness or increased central drive to the pituitary, as determined by CRH testing, plays a part in the development of the metabolic syndrome.
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Published date: 2004
Keywords:
hydrocortisone, diagnosis, non-u.s.gov't, statistics, etiology, risk factors, activity, u.s.gov't, saliva, antagonists & inhibitors, obesity, pharmacology, aged, male, cohort studies, nonparametric
Organisations:
Human Genetics, Dev Origins of Health & Disease
Identifiers
Local EPrints ID: 26109
URI: http://eprints.soton.ac.uk/id/eprint/26109
ISSN: 0026-0495
PURE UUID: 140c59ef-ed3b-4f9f-b4d5-94e85b974138
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Date deposited: 12 Apr 2006
Last modified: 16 Mar 2024 02:59
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Author:
Alexandra M.V. Ward
Author:
Peter J. Wood
Author:
David I.W. Phillips
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