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Central hypothalamic-pituitary-adrenal activity and the metabolic syndrome: studies using the corticotrophin-releasing hormone test

Ward, Alexandra M.V., Syddall, Holly E., Wood, Peter J., Dennison, Elaine M. and Phillips, David I.W. (2004) Central hypothalamic-pituitary-adrenal activity and the metabolic syndrome: studies using the corticotrophin-releasing hormone test Metabolism, 53, (6), pp. 720-726. (doi:10.1016/j.metabol.2004.01.008).

Record type: Article


A number of studies have suggested that the metabolic syndrome (principally, the combination of hypertension, glucose intolerance, and dyslipidemia) is associated with subtle dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis leading to raised circulating cortisol concentrations. The mechanisms underlying these observations are not known. We assessed the salivary cortisol response to awakening and pituitary-adrenal responses during a 100-?g human corticotrophin-releasing hormone (CRH) test and a dexamethasone-suppressed CRH test in a well-characterized group of 65-year-old men (n = 122). In the cohort from which this subgroup was drawn, there were associations between the components of the metabolic syndrome and 9AM cortisol concentration in line with previous studies. However, there were no significant associations between blood pressure, glucose tolerance, and lipid concentrations and the dynamic tests of HPA activity. We therefore found no evidence to suggest that exaggerated pituitary responsiveness or increased central drive to the pituitary, as determined by CRH testing, plays a part in the development of the metabolic syndrome.

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Published date: 2004
Keywords: hydrocortisone, diagnosis,'t, statistics, etiology, risk factors, activity,'t, saliva, antagonists & inhibitors, obesity, pharmacology, aged, male, cohort studies, nonparametric
Organisations: Human Genetics, Dev Origins of Health & Disease


Local EPrints ID: 26109
ISSN: 0026-0495
PURE UUID: 140c59ef-ed3b-4f9f-b4d5-94e85b974138
ORCID for Holly E. Syddall: ORCID iD

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Date deposited: 12 Apr 2006
Last modified: 17 Jul 2017 16:08

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Author: Alexandra M.V. Ward
Author: Holly E. Syddall ORCID iD
Author: Peter J. Wood
Author: David I.W. Phillips

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