Artificial bilayer lipid membranes (BLMs) on-chip for single molecule sensing
Artificial bilayer lipid membranes (BLMs) on-chip for single molecule sensing
A polymer microfluidic device for the formation of artificial bilayer lipid membranes (BLMs) on-chip is described. The device is fabricated from thin, transparent films of poly(methyl methacrylate), allowing for optical monitoring of the BLM. In addition, detection of single fluorescently-labeled lipid molecules using conventional epifluorescence microscopy is described.
lipid bilayers, microfluidics, rapid fabrication, single molecule detection
252-257
Sandison, Mairi E
58a34899-1348-46e3-95d9-86256e276f9a
Malleo, Daniele
d446665d-833c-47db-8a6f-ebaf172df477
Holmes, David
eeff86f7-ab4b-4795-9a01-82ce1275e34f
Berry, Richard
feadc607-0c57-4c4a-a877-d3688017140b
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
2005
Sandison, Mairi E
58a34899-1348-46e3-95d9-86256e276f9a
Malleo, Daniele
d446665d-833c-47db-8a6f-ebaf172df477
Holmes, David
eeff86f7-ab4b-4795-9a01-82ce1275e34f
Berry, Richard
feadc607-0c57-4c4a-a877-d3688017140b
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Sandison, Mairi E, Malleo, Daniele, Holmes, David, Berry, Richard and Morgan, Hywel
(2005)
Artificial bilayer lipid membranes (BLMs) on-chip for single molecule sensing.
Microtechnologies for the New Millennium 2005 SPIE.
.
Record type:
Conference or Workshop Item
(Paper)
Abstract
A polymer microfluidic device for the formation of artificial bilayer lipid membranes (BLMs) on-chip is described. The device is fabricated from thin, transparent films of poly(methyl methacrylate), allowing for optical monitoring of the BLM. In addition, detection of single fluorescently-labeled lipid molecules using conventional epifluorescence microscopy is described.
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More information
Published date: 2005
Additional Information:
Event Dates: 9-11th May 2005
Venue - Dates:
Microtechnologies for the New Millennium 2005 SPIE, 2005-05-10
Keywords:
lipid bilayers, microfluidics, rapid fabrication, single molecule detection
Organisations:
Nanoelectronics and Nanotechnology
Identifiers
Local EPrints ID: 261204
URI: http://eprints.soton.ac.uk/id/eprint/261204
PURE UUID: c0f878d1-91cb-4279-a8a6-107eeda24633
Catalogue record
Date deposited: 08 Sep 2005
Last modified: 09 Jan 2022 03:14
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Contributors
Author:
Mairi E Sandison
Author:
Daniele Malleo
Author:
David Holmes
Author:
Richard Berry
Author:
Hywel Morgan
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