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Artificial bilayer lipid membranes (BLMs) on-chip for single molecule sensing

Artificial bilayer lipid membranes (BLMs) on-chip for single molecule sensing
Artificial bilayer lipid membranes (BLMs) on-chip for single molecule sensing
A polymer microfluidic device for the formation of artificial bilayer lipid membranes (BLMs) on-chip is described. The device is fabricated from thin, transparent films of poly(methyl methacrylate), allowing for optical monitoring of the BLM. In addition, detection of single fluorescently-labeled lipid molecules using conventional epifluorescence microscopy is described.
lipid bilayers, microfluidics, rapid fabrication, single molecule detection
252-257
Sandison, Mairi E
58a34899-1348-46e3-95d9-86256e276f9a
Malleo, Daniele
d446665d-833c-47db-8a6f-ebaf172df477
Holmes, David
eeff86f7-ab4b-4795-9a01-82ce1275e34f
Berry, Richard
feadc607-0c57-4c4a-a877-d3688017140b
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Sandison, Mairi E
58a34899-1348-46e3-95d9-86256e276f9a
Malleo, Daniele
d446665d-833c-47db-8a6f-ebaf172df477
Holmes, David
eeff86f7-ab4b-4795-9a01-82ce1275e34f
Berry, Richard
feadc607-0c57-4c4a-a877-d3688017140b
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174

Sandison, Mairi E, Malleo, Daniele, Holmes, David, Berry, Richard and Morgan, Hywel (2005) Artificial bilayer lipid membranes (BLMs) on-chip for single molecule sensing. Microtechnologies for the New Millennium 2005 SPIE. pp. 252-257 .

Record type: Conference or Workshop Item (Paper)

Abstract

A polymer microfluidic device for the formation of artificial bilayer lipid membranes (BLMs) on-chip is described. The device is fabricated from thin, transparent films of poly(methyl methacrylate), allowing for optical monitoring of the BLM. In addition, detection of single fluorescently-labeled lipid molecules using conventional epifluorescence microscopy is described.

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More information

Published date: 2005
Additional Information: Event Dates: 9-11th May 2005
Venue - Dates: Microtechnologies for the New Millennium 2005 SPIE, 2005-05-11
Keywords: lipid bilayers, microfluidics, rapid fabrication, single molecule detection
Organisations: Nanoelectronics and Nanotechnology

Identifiers

Local EPrints ID: 261204
URI: https://eprints.soton.ac.uk/id/eprint/261204
PURE UUID: c0f878d1-91cb-4279-a8a6-107eeda24633
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 08 Sep 2005
Last modified: 20 Jul 2019 00:59

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