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Higher offspring birth weight predicts the metabolic syndrome in mothers but not fathers 8 years after delivery: The Pune Children's Study

Yajnik, Chittaranjan S., Joglekar, Charu V., Pandit, Anand N., Bavdekar, Ashish R., Bapat, Swati A., Bhave, Sheila A., Leary, Samantha D. and Fall, Caroline H.D. (2003) Higher offspring birth weight predicts the metabolic syndrome in mothers but not fathers 8 years after delivery: The Pune Children's Study Diabetes, 52, (8), pp. 2090-2096. (doi:10.2337/diabetes.52.8.2090).

Record type: Article

Abstract

In Europid populations, low birth weight of offspring predicts insulin resistance in the mother and cardiovascular disease in both parents. We investigated the association between birth weight of offspring and obesity and cardiovascular risk in the parents of 477 8-year-old children born at the King Edward Memorial Hospital, Pune, India.
Eight years after the birth of the child, mothers (33 years of age, n = 459) of heavier babies were taller and more obese (BMI, fat mass, and waist circumference, all P < 0.001) than mothers of lighter babies. Increasing offspring birth weight predicted higher homeostasis model assessment for insulin resistance (P < 0.01) and metabolic syndrome in mothers (P < 0.001) (adjusted for offspring sex and birth order, maternal age, and socioeconomic status) but not hyperglycemia. Fathers (39 years of age, n = 398) of heavier babies were taller and heavier, independent of maternal size (P < 0.01, both), but were not more insulin resistant.
Unlike other reports, lower offspring birth weight did not predict insulin resistance in fathers. Thus, urban Indian parents have a higher risk of being obese 8 years after delivery of a heavier child. Mothers but not fathers of heavier babies also have a higher risk of being insulin resistant and developing the metabolic syndrome. Our findings highlight the need for a better understanding of the relation between fetal growth and future health before contemplating public health interventions to improve fetal growth.

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Published date: August 2003

Identifiers

Local EPrints ID: 26136
URI: http://eprints.soton.ac.uk/id/eprint/26136
ISSN: 0012-1797
PURE UUID: ccaad0f6-afd9-4d58-a3b5-26eb3c3b9bab

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Date deposited: 12 Apr 2006
Last modified: 17 Jul 2017 16:08

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Contributors

Author: Chittaranjan S. Yajnik
Author: Charu V. Joglekar
Author: Anand N. Pandit
Author: Ashish R. Bavdekar
Author: Swati A. Bapat
Author: Sheila A. Bhave
Author: Samantha D. Leary

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