N-3 polyunsaturated fatty acids and inflammation in the arterial wall
N-3 polyunsaturated fatty acids and inflammation in the arterial wall
Atherosclerosis, leading to cardiovascular disease, is a chronic condition involving a strong inflammatory component. There is evidence that the n-3 polyunsaturated fatty acids (PUFA) present in oily fish and fish oils protect against cardiovascular disease. While these fatty acids have well-recognised effects on plasma triacylglycerol concentrations, it is likely that they exert beneficial effects through other mechanisms in addition. A large body of evidence suggests that the n-3 PUFA have anti-inflammatory properties, some of which may be manifested in the arterial wall, either directly or indirectly, to modulate the progression of atherosclerosis. This review critically evaluates the evidence for the anti-inflammatory effects of the n-3 PUFA in cells and on pathways which have a direct influence on atherogenesis in the arterial wall.
337-354
Yaqoob, P.
eb74426f-4486-41ca-bb29-2e3ce3e65b68
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
2003
Yaqoob, P.
eb74426f-4486-41ca-bb29-2e3ce3e65b68
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Yaqoob, P. and Calder, P.C.
(2003)
N-3 polyunsaturated fatty acids and inflammation in the arterial wall.
European Journal of Medical Research, 8 (8), .
Abstract
Atherosclerosis, leading to cardiovascular disease, is a chronic condition involving a strong inflammatory component. There is evidence that the n-3 polyunsaturated fatty acids (PUFA) present in oily fish and fish oils protect against cardiovascular disease. While these fatty acids have well-recognised effects on plasma triacylglycerol concentrations, it is likely that they exert beneficial effects through other mechanisms in addition. A large body of evidence suggests that the n-3 PUFA have anti-inflammatory properties, some of which may be manifested in the arterial wall, either directly or indirectly, to modulate the progression of atherosclerosis. This review critically evaluates the evidence for the anti-inflammatory effects of the n-3 PUFA in cells and on pathways which have a direct influence on atherogenesis in the arterial wall.
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Published date: 2003
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Local EPrints ID: 26143
URI: http://eprints.soton.ac.uk/id/eprint/26143
ISSN: 0949-2321
PURE UUID: 036d7b90-d572-434e-966e-d3561a5781c1
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Date deposited: 24 Apr 2006
Last modified: 31 May 2023 01:33
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P. Yaqoob
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