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Risk factors for knee osteoarthritis in Japanese women: heavy weight, previous joint injuries, and occupational activities

Yoshimura, Noriko, Nishioka, Shingo, Kinoshita, Hirofumi, Hori, Noriaki, Nishioka, Taira, Ryujin, Masahiko, Mantani, Yoshihiko, Miyake, Mariko, Coggon, David and Cooper, Cyrus (2004) Risk factors for knee osteoarthritis in Japanese women: heavy weight, previous joint injuries, and occupational activities The Journal of Rheumatology, 31, (1), pp. 157-162.

Record type: Article


Objective: Risk of knee osteoarthritis (OA) associated with constitutional factors, history of joint injuries, and occupational factors was assessed in a case-control study among women in Japan. Results were contrasted with a comparable study in Britain.
Methods: The study covered 3 health districts in Japan. Cases were women aged ³ 45 years old, diagnosed with knee OA by orthopedic physicians utilizing radiography. No cases displayed established causes of secondary OA. Controls selected randomly from the general population were individually matched to each case for age, sex, and residential district. Subjects were interviewed using structured questionnaires to determine medical history, including history of joint injury, physical activity, socioeconomic factors, and occupation. Height and weight were measured.
Results: Interviews were obtained from 101 female cases and controls. The highest third of heaviest body weight in the past [high (> 62.0 kg) vs low (< 55 kg) odds ratio = 4.42, 95% confidence interval 1.17–16.64], previous injury to the knee (OR 7.11, 95% CI 2.40–21.09), sedentary work during initial employment (OR 0.35, 95% CI 0.15–0.84), and total working years (OR 1.05, 95% CI 1.01–1.08) represented independent factors associated with knee OA, after controlling for other potential risk factors.
Conclusion: Heavy weight in the past appears to represent a risk factor for knee OA among women in Japan, as reported in Britain. Constitutional factors may represent important determinants for knee OA, regardless of race. Previous injury to the knee and occupational factors are also associated with knee OA in both Britain and Japan, although characteristic activities for work vary.

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Published date: 2004
Keywords: osteoarthritis, knee joint, case-control study, heavy weight, joint injuries, occupational activities
Organisations: Community Clinical Sciences, Dev Origins of Health & Disease


Local EPrints ID: 26148
ISSN: 0315-162X
PURE UUID: 8e2a475a-2030-491a-b286-e2fb4add142f
ORCID for David Coggon: ORCID iD
ORCID for Cyrus Cooper: ORCID iD

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Date deposited: 12 Apr 2006
Last modified: 17 Jul 2017 16:08

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Author: Noriko Yoshimura
Author: Shingo Nishioka
Author: Hirofumi Kinoshita
Author: Noriaki Hori
Author: Taira Nishioka
Author: Masahiko Ryujin
Author: Yoshihiko Mantani
Author: Mariko Miyake
Author: David Coggon ORCID iD
Author: Cyrus Cooper ORCID iD

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