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Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged Caucasian men

Record type: Article

The insulin-sensitizing effect of adiponectin (1–4) is mediated via adiponectin receptors (AdipoR1 and AdipoR2) (5). AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is also expressed in the liver, with lower levels of expression in skeletal muscle (5). Both receptors are expressed in adipose tissue (6) and pancreatic ß-cells (7).
It has been shown recently that expression of AdipoRs in human skeletal muscle is correlated with insulin sensitivity (8). Because central obesity is associated with insulin resistance, we have undertaken detailed measurements of body fatness with bioimpedance, dual-energy X-ray absorbtiometry (DEXA), and five-slice magnetic resonance imaging (MRI) through the abdomen. We have determined whether expression of AdipoRs was associated with body fatness and in particular with measures of central obesity.

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Citation

Zhang, Junlong, Holt, Helen, Wang, Chunli, Hadid, Omar H. and Byrne, Christopher D. (2005) Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged Caucasian men Diabetes Care, 28, (8), pp. 2058-2060. (doi:10.2337/diacare.28.8.2058).

More information

Published date: August 2005
Additional Information: Pathophysiology/complications: brief report

Identifiers

Local EPrints ID: 26156
URI: http://eprints.soton.ac.uk/id/eprint/26156
ISSN: 1935-5548
PURE UUID: 1bc97dde-591d-42b9-b6d4-0fe30504a5b6

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Date deposited: 19 Apr 2006
Last modified: 17 Jul 2017 16:08

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Contributors

Author: Junlong Zhang
Author: Helen Holt
Author: Chunli Wang
Author: Omar H. Hadid

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