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Maternal dietary iron restriction modulates hepatic lipid metabolism in the fetuses

Zhang, Junlong, Lewis, Rohan M., Wang, Chunli, Hales, Nicholas and Byrne, Christopher D. (2005) Maternal dietary iron restriction modulates hepatic lipid metabolism in the fetuses American Journal of Physiology- Regulatory, Integrative and Comparative Physiology, 288, (1), R104-R111. (doi:10.1152/ajpregu.00343.2004).

Record type: Article


Maternal dietary Fe restriction reduced fasting plasma cholesterol and triglyceride (TG) concentrations in the fetuses, as well as decreased plasma TG levels in the adult offspring. To investigate how maternal Fe restriction was affecting fetal lipid metabolism, we investigated whether there were changes in liver lipid metabolism in the full-term fetuses. There was a ~27% (P < 0.05) increase in cholesterol but 29% reduction (P = 0.01) in TG concentrations in the liver of the Fe-restricted fetuses. Hepatic mRNA levels of cholesterol 7 hydroxylase and liver X receptor-? (LXR?) were reduced by ~50% (P < 0.01) and ~34% (P < 0.01), respectively. As LXR? regulates expression of sterol response element binding protein-1c (SREBP-1c) expression, we measured SREBP-1c expression. There was an ~43% (P < 0.001) reduction in mRNA levels of SREBP-1c and its response genes, including acetyl-CoA carboxylase by ~35% (P = 0.01), fatty acid synthase by ~18% (P = 0.05), and diacylglycerol acyltransferase by ~19% (P = 0.03). Furthermore, protein levels of CD36 were reduced by ~27% (P = 0.02) in Fe-restricted fetuses. In conclusion, changes in liver cholesterol and TG concentrations in Fe-restricted fetuses may be coordinated through reduced expression of heme-containing cholesterol 7 hydroxylase and its regulator LXR?, mainly via downregulation of expression of genes in bile acid synthesis and fatty acid synthesis pathways.

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Published date: 2005
Keywords: cholesterol, cholesterol 7 alpha hydroxylase, liver x receptor-alpha, fetus


Local EPrints ID: 26158
ISSN: 0363-6119
PURE UUID: 8fa8ac59-fce6-4789-9a2d-5fda58bd9ea7
ORCID for Rohan M. Lewis: ORCID iD

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Date deposited: 19 Apr 2006
Last modified: 17 Jul 2017 16:08

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Author: Junlong Zhang
Author: Rohan M. Lewis ORCID iD
Author: Chunli Wang
Author: Nicholas Hales

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