Letters: observations. Plasma adiponectin concentrations are independently predicted by fat insulin sensitivity in women and by muscle insulin sensitivity in men
Letters: observations. Plasma adiponectin concentrations are independently predicted by fat insulin sensitivity in women and by muscle insulin sensitivity in men
Adiponectin is an abundant plasma protein, mainly secreted by adipocytes and closely linked to insulin sensitivity (1–4). Plasma adiponectin independently correlates with insulin sensitivity (5). Since women have greater plasma adiponectin levels than men (5–7), we determined sex-specific differences in associations between plasma adiponectin and tissue-specific insulin sensitivity in skeletal muscle, liver, and fat.
Plasma adiponectin concentrations were measured (intra-assay coefficient of variation <4%) in 28 men and 28 women (6 men and 6 women had impaired glucose tolerance according to World Health Organization criteria). Insulin sensitivity in skeletal muscle, liver, and fat was determined by insulin-mediated whole-body glucose disposal (M values), suppression of hepatic glucose output evaluated during a hyperinsulinemic-euglycemic clamp, and suppression of free fatty acid (FFA).
755-756
Zhang, Junlong
68a8fa77-c5db-4b34-aa9a-fbad6860155f
Holt, Richard I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393
Wild, Sarah H.
b790195a-4aae-421b-81f7-2c18c96e6870
Poole, Ruth B.
4f0fd2d6-222b-4d46-a869-7ff1cad81123
Holt, Helen
91299fb2-77f1-422f-81fa-86d5fdd0b1fb
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
2005
Zhang, Junlong
68a8fa77-c5db-4b34-aa9a-fbad6860155f
Holt, Richard I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393
Wild, Sarah H.
b790195a-4aae-421b-81f7-2c18c96e6870
Poole, Ruth B.
4f0fd2d6-222b-4d46-a869-7ff1cad81123
Holt, Helen
91299fb2-77f1-422f-81fa-86d5fdd0b1fb
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Zhang, Junlong, Holt, Richard I.G., Wild, Sarah H., Poole, Ruth B., Holt, Helen and Byrne, Christopher D.
(2005)
Letters: observations. Plasma adiponectin concentrations are independently predicted by fat insulin sensitivity in women and by muscle insulin sensitivity in men.
Diabetes Care, 28 (3), .
(doi:10.2337/diacare.28.3.755).
Abstract
Adiponectin is an abundant plasma protein, mainly secreted by adipocytes and closely linked to insulin sensitivity (1–4). Plasma adiponectin independently correlates with insulin sensitivity (5). Since women have greater plasma adiponectin levels than men (5–7), we determined sex-specific differences in associations between plasma adiponectin and tissue-specific insulin sensitivity in skeletal muscle, liver, and fat.
Plasma adiponectin concentrations were measured (intra-assay coefficient of variation <4%) in 28 men and 28 women (6 men and 6 women had impaired glucose tolerance according to World Health Organization criteria). Insulin sensitivity in skeletal muscle, liver, and fat was determined by insulin-mediated whole-body glucose disposal (M values), suppression of hepatic glucose output evaluated during a hyperinsulinemic-euglycemic clamp, and suppression of free fatty acid (FFA).
Text
755.pdf
- Version of Record
Restricted to Repository staff only
Request a copy
More information
Published date: 2005
Identifiers
Local EPrints ID: 26159
URI: http://eprints.soton.ac.uk/id/eprint/26159
ISSN: 1935-5548
PURE UUID: daa8f978-1635-459f-9641-c9b3e0329769
Catalogue record
Date deposited: 19 Apr 2006
Last modified: 16 Mar 2024 03:19
Export record
Altmetrics
Contributors
Author:
Junlong Zhang
Author:
Sarah H. Wild
Author:
Ruth B. Poole
Author:
Helen Holt
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
