Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG and BRCA2 6174delT mutations: a combined analysis of 22 population based studies
Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG and BRCA2 6174delT mutations: a combined analysis of 22 population based studies
A recent report estimated the breast cancer risks in carriers of the three Ashkenazi founder mutations to be higher than previously published estimates derived from population based studies. In an attempt to confirm this, the breast and ovarian cancer risks associated with the three Ashkenazi founder mutations were estimated using families included in a previous meta-analysis of populatrion based studies. The estimated breast cancer risks for each of the founder BRCA1 and BRCA2 mutations were similar to the corresponding estimates based on all BRCA1 or BRCA2 mutations in the meta-analysis. These estimates appear to be consistent with the observed prevalence of the mutations in the Ashkenazi Jewish population.
BRCA1/2 penetrance, meta-analysis, founder mutation, Ashkenazi
602-603
Antoniou, A.C.
6dc040a0-bd30-4178-995b-ca6f237949e1
Pharoah, P.D.
cf2add80-0197-460a-856c-43de8e1ab3ed
Narod, S.
060842b6-2540-40a7-adac-73678f9a8cf3
Risch, H.A.
3090c43b-ed4d-45a9-9621-e4fc2c6148e2
Eyfjord, J.E.
31226243-20e8-466a-9a19-9c4b50c81092
Hopper, J.L.
4d03ec4a-627b-45e3-8c73-6bd2959ac47e
Olsson, H.
f98cd153-ac08-4ada-8795-f73c5118c0e8
Johannsson, O.
0da798b7-d0b1-4f35-bdbe-490f710ff750
Borg, A.
cdead415-c3d4-419e-a751-a5fe14a301bc
Pasini, B.
827867df-9204-4674-813e-3cab4fdc8720
Radice, P.
a7f1a7a5-ba5f-4c21-8fa7-b394a5b5d8b9
Manoukian, S.
811c6f96-2a85-4318-a752-cc3b7ec3d2fd
Eccles, D.M.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Tang, N.
91a2749b-d6bd-41d3-98c2-8dbf8201caf0
Olah, E.
ca95b0ca-289f-4034-9930-0dff3a67bb7c
Nton-Culver, H.
e0e06a79-8a62-4012-8a7e-473199adef63
Warner, E.
c3da7dad-dd97-44f0-8d97-52e9872539ae
Lubinski, J.
63a971db-39b7-4e5a-a932-8a8c645ea72f
Gronwald, J.
ea39599c-3dcd-4558-9a25-d19c6bbf0355
Gorski, B.
4760965c-c91c-4c84-946b-86722d77f08e
Tulinius, H.
05980527-11d3-40b0-9875-26f609f11231
Thorlacius, S.
768c0bdd-354e-4628-a98c-99b4530d3c01
Eerola, H.
dcc9a0cb-b993-4fb3-bfd1-36cf9001b419
Nevanlinna, H.
188d5d63-7183-49de-8721-242adee86703
Syrjakoski, K.
8270a3fe-d808-4c54-8a22-11a57ab4b666
Kallioniemi, O.P.
fc1892aa-72fb-4a59-921e-6803e86812cf
Thompson, D.
f02914bc-43d6-4944-91f6-6ee85e697788
Evans, C.
222540af-62ce-4843-87ea-e73a2480f6a7
Peto, J.
e6de4fa9-83fe-4cd8-8ade-00571799204d
Lalloo, F.
60a2edba-59dd-4e37-9b3d-9eff7f8f7106
Evans, D.G.
b58c99fc-4da0-4d7e-b140-f22307befe5e
Easton, D.F.
ef4b7694-86fa-4568-969f-d0ee512127fc
2005
Antoniou, A.C.
6dc040a0-bd30-4178-995b-ca6f237949e1
Pharoah, P.D.
cf2add80-0197-460a-856c-43de8e1ab3ed
Narod, S.
060842b6-2540-40a7-adac-73678f9a8cf3
Risch, H.A.
3090c43b-ed4d-45a9-9621-e4fc2c6148e2
Eyfjord, J.E.
31226243-20e8-466a-9a19-9c4b50c81092
Hopper, J.L.
4d03ec4a-627b-45e3-8c73-6bd2959ac47e
Olsson, H.
f98cd153-ac08-4ada-8795-f73c5118c0e8
Johannsson, O.
0da798b7-d0b1-4f35-bdbe-490f710ff750
Borg, A.
cdead415-c3d4-419e-a751-a5fe14a301bc
Pasini, B.
827867df-9204-4674-813e-3cab4fdc8720
Radice, P.
a7f1a7a5-ba5f-4c21-8fa7-b394a5b5d8b9
Manoukian, S.
811c6f96-2a85-4318-a752-cc3b7ec3d2fd
Eccles, D.M.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Tang, N.
91a2749b-d6bd-41d3-98c2-8dbf8201caf0
Olah, E.
ca95b0ca-289f-4034-9930-0dff3a67bb7c
Nton-Culver, H.
e0e06a79-8a62-4012-8a7e-473199adef63
Warner, E.
c3da7dad-dd97-44f0-8d97-52e9872539ae
Lubinski, J.
63a971db-39b7-4e5a-a932-8a8c645ea72f
Gronwald, J.
ea39599c-3dcd-4558-9a25-d19c6bbf0355
Gorski, B.
4760965c-c91c-4c84-946b-86722d77f08e
Tulinius, H.
05980527-11d3-40b0-9875-26f609f11231
Thorlacius, S.
768c0bdd-354e-4628-a98c-99b4530d3c01
Eerola, H.
dcc9a0cb-b993-4fb3-bfd1-36cf9001b419
Nevanlinna, H.
188d5d63-7183-49de-8721-242adee86703
Syrjakoski, K.
8270a3fe-d808-4c54-8a22-11a57ab4b666
Kallioniemi, O.P.
fc1892aa-72fb-4a59-921e-6803e86812cf
Thompson, D.
f02914bc-43d6-4944-91f6-6ee85e697788
Evans, C.
222540af-62ce-4843-87ea-e73a2480f6a7
Peto, J.
e6de4fa9-83fe-4cd8-8ade-00571799204d
Lalloo, F.
60a2edba-59dd-4e37-9b3d-9eff7f8f7106
Evans, D.G.
b58c99fc-4da0-4d7e-b140-f22307befe5e
Easton, D.F.
ef4b7694-86fa-4568-969f-d0ee512127fc