Assembly and export of MHC class I peptide ligands


Antoniou, Antony N., Powis, Simon J. and Elliott, Tim (2003) Assembly and export of MHC class I peptide ligands Current Opinion in Immunology, 15, (1), pp. 75-81. (doi:10.1016/S0952-7915(02)00010-9).

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Description/Abstract

During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules. These interactions culminate in the trafficking of MHC class I molecules to the cell surface and presentation of peptide to CD8+ T lymphocytes. Recent studies have revealed just how important these early interactions are, and how they influence the quality control of assembly and the optimisation of peptide–ligand binding.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S0952-7915(02)00010-9
ISSNs: 0952-7915 (print)
Related URLs:
Subjects: R Medicine > R Medicine (General)
Q Science > QR Microbiology > QR180 Immunology
ePrint ID: 26200
Date :
Date Event
2003Published
Date Deposited: 20 Apr 2006
Last Modified: 16 Apr 2017 22:34
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/26200

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