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Assembly and export of MHC class I peptide ligands

Record type: Article

During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules. These interactions culminate in the trafficking of MHC class I molecules to the cell surface and presentation of peptide to CD8+ T lymphocytes. Recent studies have revealed just how important these early interactions are, and how they influence the quality control of assembly and the optimisation of peptide–ligand binding.

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Citation

Antoniou, Antony N., Powis, Simon J. and Elliott, Tim (2003) Assembly and export of MHC class I peptide ligands Current Opinion in Immunology, 15, (1), pp. 75-81. (doi:10.1016/S0952-7915(02)00010-9).

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Published date: 2003

Identifiers

Local EPrints ID: 26200
URI: http://eprints.soton.ac.uk/id/eprint/26200
ISSN: 0952-7915
PURE UUID: 972c1bb7-0082-4eb8-8f98-a71c56b92b99
ORCID for Tim Elliott: ORCID iD orcid.org/0000-0003-1097-0222

Catalogue record

Date deposited: 20 Apr 2006
Last modified: 17 Jul 2017 16:08

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Contributors

Author: Antony N. Antoniou
Author: Simon J. Powis
Author: Tim Elliott ORCID iD

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