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Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events

Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events
Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events
Isotype switch commonly follows onset of somatic hypermutation in the germinal center (GC), with activation-induced cytidine deaminase (AID) as a prerequisite. Mantle cell lymphoma (MCL) with t(11;14) includes a subset with unmutated (UM) and a minor subset with mutated (MUT) VH genes. Here, we investigated whether switch events and AID expression occur in MCL. In 4 of 6 UM and 4 of 7 MUT MCLs, alternative tumor-derived C?,?,? transcripts were identified. AID transcripts, including a splice variant, were common to both subsets. AID expression correlated with switch in 8 of 8 cases, but in 3 of 5 cases it occurred with switch absent. Circle transcripts (I?-Cµ/I?-Cµ) were identified in 5 of 7 evaluated cases. In 1 of 12 cases, 12% of tumor cells expressed immunoglobulin L-restricted surface IgA. Ongoing switch recombination events appear to be a feature of MCL, likely restricted to a minor tumor subpopulation, with occasional variant sIg expression. UM MCLs implicate origins from pre-GC B cells and reveal switch events at ectopic sites. (Blood. 2004;103:2795-2798)
0006-4971
2795-2798
Babbage, Gavin
d2036377-f36a-4a4a-8634-4b0394dffe28
Garand, Richard
5ad75ec9-a096-4612-ac4c-a096ad9da731
Robillard, Nelly
9f527c6c-3637-4562-80b1-08c52aa518a6
Zojer, Niklas
88a51a4d-0b56-4832-bc0f-f102fc49d656
Stevenson, Freda K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Sahota, Surinder S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Babbage, Gavin
d2036377-f36a-4a4a-8634-4b0394dffe28
Garand, Richard
5ad75ec9-a096-4612-ac4c-a096ad9da731
Robillard, Nelly
9f527c6c-3637-4562-80b1-08c52aa518a6
Zojer, Niklas
88a51a4d-0b56-4832-bc0f-f102fc49d656
Stevenson, Freda K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Sahota, Surinder S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8

Babbage, Gavin, Garand, Richard, Robillard, Nelly, Zojer, Niklas, Stevenson, Freda K. and Sahota, Surinder S. (2004) Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events. Blood, 103 (7), 2795-2798. (doi:10.1182/blood-2003-05-1632).

Record type: Article

Abstract

Isotype switch commonly follows onset of somatic hypermutation in the germinal center (GC), with activation-induced cytidine deaminase (AID) as a prerequisite. Mantle cell lymphoma (MCL) with t(11;14) includes a subset with unmutated (UM) and a minor subset with mutated (MUT) VH genes. Here, we investigated whether switch events and AID expression occur in MCL. In 4 of 6 UM and 4 of 7 MUT MCLs, alternative tumor-derived C?,?,? transcripts were identified. AID transcripts, including a splice variant, were common to both subsets. AID expression correlated with switch in 8 of 8 cases, but in 3 of 5 cases it occurred with switch absent. Circle transcripts (I?-Cµ/I?-Cµ) were identified in 5 of 7 evaluated cases. In 1 of 12 cases, 12% of tumor cells expressed immunoglobulin L-restricted surface IgA. Ongoing switch recombination events appear to be a feature of MCL, likely restricted to a minor tumor subpopulation, with occasional variant sIg expression. UM MCLs implicate origins from pre-GC B cells and reveal switch events at ectopic sites. (Blood. 2004;103:2795-2798)

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More information

Published date: 2004
Additional Information: Neoplasia, brief report

Identifiers

Local EPrints ID: 26207
URI: https://eprints.soton.ac.uk/id/eprint/26207
ISSN: 0006-4971
PURE UUID: 52e97046-c728-43fb-bff0-fd4bf31130d1
ORCID for Freda K. Stevenson: ORCID iD orcid.org/0000-0002-0933-5021

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Date deposited: 24 Apr 2006
Last modified: 20 Jul 2019 01:16

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