The University of Southampton
University of Southampton Institutional Repository

High incidence of spontaneous autoimmune thyroiditis in immunocompetent self-reactive human T cell receptor transgenic mice

High incidence of spontaneous autoimmune thyroiditis in immunocompetent self-reactive human T cell receptor transgenic mice
High incidence of spontaneous autoimmune thyroiditis in immunocompetent self-reactive human T cell receptor transgenic mice
Autoantigen-specific TCR transgenic mice allow us to assess the role of T cells in autoimmunity. We have recently generated humanized TAZ10 transgenic mice expressing the human TCR specific for the immunodominant epitope of thyroid peroxidase (TPO). We have shown that these transgenic mice do not undergo tolerance in vivo and that on Rag deficient background they are susceptible to spontaneous autoimmune thyroiditis. Here we show that, in contrast to other transgenic models of autoimmunity, almost all TCR+Rag1+ (T+R+) T cells are activated in vivo leading to the development of spontaneous autoimmune thyroiditis. In these mice, disease is also accompanied by a significant reduction of CD4+CD25hi regulatory T cells. These data indicate that the pathogenic activity of the self-reactive TCR can circumvent the regulatory function operated by the non-transgenic T cells that are normally present in T+R+ mice, leading to autoimmunity.
humanized model, tcr, transgenic, thyroiditis, autoimmunity, t cells
0896-8411
85-91
Badami, Ester
15b5c816-4d23-4da5-acf2-81d4a040aed8
Maiuri, Luigi
999bc98b-70b2-4b19-ad2e-788f7f531f61
Quaratino, Sonia
a17d78fe-6c03-4775-83e3-53f9d511ae70
Badami, Ester
15b5c816-4d23-4da5-acf2-81d4a040aed8
Maiuri, Luigi
999bc98b-70b2-4b19-ad2e-788f7f531f61
Quaratino, Sonia
a17d78fe-6c03-4775-83e3-53f9d511ae70

Badami, Ester, Maiuri, Luigi and Quaratino, Sonia (2005) High incidence of spontaneous autoimmune thyroiditis in immunocompetent self-reactive human T cell receptor transgenic mice. Journal of autoimmunity, 24 (2), 85-91.

Record type: Article

Abstract

Autoantigen-specific TCR transgenic mice allow us to assess the role of T cells in autoimmunity. We have recently generated humanized TAZ10 transgenic mice expressing the human TCR specific for the immunodominant epitope of thyroid peroxidase (TPO). We have shown that these transgenic mice do not undergo tolerance in vivo and that on Rag deficient background they are susceptible to spontaneous autoimmune thyroiditis. Here we show that, in contrast to other transgenic models of autoimmunity, almost all TCR+Rag1+ (T+R+) T cells are activated in vivo leading to the development of spontaneous autoimmune thyroiditis. In these mice, disease is also accompanied by a significant reduction of CD4+CD25hi regulatory T cells. These data indicate that the pathogenic activity of the self-reactive TCR can circumvent the regulatory function operated by the non-transgenic T cells that are normally present in T+R+ mice, leading to autoimmunity.

Full text not available from this repository.

More information

Submitted date: 20 September 2004
Published date: March 2005
Keywords: humanized model, tcr, transgenic, thyroiditis, autoimmunity, t cells

Identifiers

Local EPrints ID: 26208
URI: https://eprints.soton.ac.uk/id/eprint/26208
ISSN: 0896-8411
PURE UUID: e9b2c2b5-aa6b-42ac-ae1a-9d55278d2453

Catalogue record

Date deposited: 07 Apr 2006
Last modified: 22 Oct 2017 00:35

Export record

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×