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High incidence of spontaneous autoimmune thyroiditis in immunocompetent self-reactive human T cell receptor transgenic mice

Record type: Article

Autoantigen-specific TCR transgenic mice allow us to assess the role of T cells in autoimmunity. We have recently generated humanized TAZ10 transgenic mice expressing the human TCR specific for the immunodominant epitope of thyroid peroxidase (TPO). We have shown that these transgenic mice do not undergo tolerance in vivo and that on Rag deficient background they are susceptible to spontaneous autoimmune thyroiditis. Here we show that, in contrast to other transgenic models of autoimmunity, almost all TCR+Rag1+ (T+R+) T cells are activated in vivo leading to the development of spontaneous autoimmune thyroiditis. In these mice, disease is also accompanied by a significant reduction of CD4+CD25hi regulatory T cells. These data indicate that the pathogenic activity of the self-reactive TCR can circumvent the regulatory function operated by the non-transgenic T cells that are normally present in T+R+ mice, leading to autoimmunity.

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Citation

Badami, Ester, Maiuri, Luigi and Quaratino, Sonia (2005) High incidence of spontaneous autoimmune thyroiditis in immunocompetent self-reactive human T cell receptor transgenic mice Journal of autoimmunity, 24, (2), pp. 85-91. (doi:10.1016/j.jaut.2005.01.003).

More information

Submitted date: 20 September 2004
Published date: March 2005
Keywords: humanized model, tcr, transgenic, thyroiditis, autoimmunity, t cells

Identifiers

Local EPrints ID: 26208
URI: http://eprints.soton.ac.uk/id/eprint/26208
ISSN: 0896-8411
PURE UUID: e9b2c2b5-aa6b-42ac-ae1a-9d55278d2453

Catalogue record

Date deposited: 07 Apr 2006
Last modified: 17 Jul 2017 16:08

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Contributors

Author: Ester Badami
Author: Luigi Maiuri
Author: Sonia Quaratino

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