Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer
Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer
Background: A growing body of evidence suggests that variations in the levels of folate may contribute to the development of cancer. A functional polymorphic variant (C?T substitution at nucleotide 677) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene results in the conversion of an alanine to a valine and may modify the risk of breast and other cancers.
Method: We have investigated the possible influence of this MTHFR variant on breast cancer risk in a case-control study of 233 healthy women and 335 women who had breast cancer that occurred under the age of 40 years, bilateral breast cancer or a family history of breast cancer.
Results: A significant excess of the valine genotypes was observed among the cases (odds ratio 1.43, 95% confidence interval 1.02–2.00). The effect was more pronounced among the cases with a breast cancer diagnosis under the age of 40 years, with an odds ratio of 1.66 (95% confidence interval 1.12–2.41). A nonsignificant excess of the valine genotypes was observed among the cases with a family history of breast cancer or bilateral breast cancer.
Conclusions: The low activity C677T (valine) genotype of MTHFR may increase the risk of early onset breast cancer.
breast cancer, mthfr, polymorphism
Campbell, Ian G.
681789cb-d416-4722-9ba8-449c7af96673
Baxter, Simon W.
f967c87a-2288-499e-b3ca-c288913050b8
Eccles, Diana M.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Choong, David Y. H.
2011abc8-44bb-4fdc-b39a-b0ab947a287f
2002
Campbell, Ian G.
681789cb-d416-4722-9ba8-449c7af96673
Baxter, Simon W.
f967c87a-2288-499e-b3ca-c288913050b8
Eccles, Diana M.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Choong, David Y. H.
2011abc8-44bb-4fdc-b39a-b0ab947a287f
Campbell, Ian G., Baxter, Simon W., Eccles, Diana M. and Choong, David Y. H.
(2002)
Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer.
Breast Cancer Research, 4 (6).
(doi:10.1186/bcr457).
Abstract
Background: A growing body of evidence suggests that variations in the levels of folate may contribute to the development of cancer. A functional polymorphic variant (C?T substitution at nucleotide 677) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene results in the conversion of an alanine to a valine and may modify the risk of breast and other cancers.
Method: We have investigated the possible influence of this MTHFR variant on breast cancer risk in a case-control study of 233 healthy women and 335 women who had breast cancer that occurred under the age of 40 years, bilateral breast cancer or a family history of breast cancer.
Results: A significant excess of the valine genotypes was observed among the cases (odds ratio 1.43, 95% confidence interval 1.02–2.00). The effect was more pronounced among the cases with a breast cancer diagnosis under the age of 40 years, with an odds ratio of 1.66 (95% confidence interval 1.12–2.41). A nonsignificant excess of the valine genotypes was observed among the cases with a family history of breast cancer or bilateral breast cancer.
Conclusions: The low activity C677T (valine) genotype of MTHFR may increase the risk of early onset breast cancer.
This record has no associated files available for download.
More information
Published date: 2002
Additional Information:
Research Article
Keywords:
breast cancer, mthfr, polymorphism
Identifiers
Local EPrints ID: 26232
URI: http://eprints.soton.ac.uk/id/eprint/26232
ISSN: 1465-5411
PURE UUID: 5890c50a-93a5-4b1d-a4e8-f8e4797e313d
Catalogue record
Date deposited: 21 Apr 2006
Last modified: 16 Mar 2024 02:39
Export record
Altmetrics
Contributors
Author:
Ian G. Campbell
Author:
Simon W. Baxter
Author:
David Y. H. Choong
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
Loading...
View more statistics