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Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer

Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer
Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer
Background: A growing body of evidence suggests that variations in the levels of folate may contribute to the development of cancer. A functional polymorphic variant (C?T substitution at nucleotide 677) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene results in the conversion of an alanine to a valine and may modify the risk of breast and other cancers.
Method: We have investigated the possible influence of this MTHFR variant on breast cancer risk in a case-control study of 233 healthy women and 335 women who had breast cancer that occurred under the age of 40 years, bilateral breast cancer or a family history of breast cancer.
Results: A significant excess of the valine genotypes was observed among the cases (odds ratio 1.43, 95% confidence interval 1.02–2.00). The effect was more pronounced among the cases with a breast cancer diagnosis under the age of 40 years, with an odds ratio of 1.66 (95% confidence interval 1.12–2.41). A nonsignificant excess of the valine genotypes was observed among the cases with a family history of breast cancer or bilateral breast cancer.
Conclusions: The low activity C677T (valine) genotype of MTHFR may increase the risk of early onset breast cancer.
breast cancer, mthfr, polymorphism
1465-5411
Campbell, Ian G.
681789cb-d416-4722-9ba8-449c7af96673
Baxter, Simon W.
f967c87a-2288-499e-b3ca-c288913050b8
Eccles, Diana M.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Choong, David Y. H.
2011abc8-44bb-4fdc-b39a-b0ab947a287f
Campbell, Ian G.
681789cb-d416-4722-9ba8-449c7af96673
Baxter, Simon W.
f967c87a-2288-499e-b3ca-c288913050b8
Eccles, Diana M.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Choong, David Y. H.
2011abc8-44bb-4fdc-b39a-b0ab947a287f

Campbell, Ian G., Baxter, Simon W., Eccles, Diana M. and Choong, David Y. H. (2002) Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer. Breast Cancer Research, 4 (6). (doi:10.1186/bcr457).

Record type: Article

Abstract

Background: A growing body of evidence suggests that variations in the levels of folate may contribute to the development of cancer. A functional polymorphic variant (C?T substitution at nucleotide 677) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene results in the conversion of an alanine to a valine and may modify the risk of breast and other cancers.
Method: We have investigated the possible influence of this MTHFR variant on breast cancer risk in a case-control study of 233 healthy women and 335 women who had breast cancer that occurred under the age of 40 years, bilateral breast cancer or a family history of breast cancer.
Results: A significant excess of the valine genotypes was observed among the cases (odds ratio 1.43, 95% confidence interval 1.02–2.00). The effect was more pronounced among the cases with a breast cancer diagnosis under the age of 40 years, with an odds ratio of 1.66 (95% confidence interval 1.12–2.41). A nonsignificant excess of the valine genotypes was observed among the cases with a family history of breast cancer or bilateral breast cancer.
Conclusions: The low activity C677T (valine) genotype of MTHFR may increase the risk of early onset breast cancer.

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More information

Published date: 2002
Additional Information: Research Article
Keywords: breast cancer, mthfr, polymorphism

Identifiers

Local EPrints ID: 26232
URI: http://eprints.soton.ac.uk/id/eprint/26232
ISSN: 1465-5411
PURE UUID: 5890c50a-93a5-4b1d-a4e8-f8e4797e313d

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Date deposited: 21 Apr 2006
Last modified: 15 Jul 2019 19:14

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Contributors

Author: Ian G. Campbell
Author: Simon W. Baxter
Author: Diana M. Eccles
Author: David Y. H. Choong

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