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No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer

No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer
No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer
A functional T to G germline polymorphism in the promoter region of MDM2 (SNP309) has been reported to profoundly accelerate tumor formation suggesting that it may also represent a powerful cancer predisposing allele. To investigate the role of SNP309 in cancer predisposition we undertook a case-control study of this polymorphism among 351 women diagnosed with breast cancer, 302 women diagnosed with ovarian and 258 female controls from a British population. The GG genotype was not associated with either breast cancer (OR 1.04, 95% CI 0.67-1.60) or ovarian cancer (OR 0.86, 95% CI 0.53-1.37). This study has found no evidence that the GG genotype of the MDM2 SNP309 polymorphism is associated with early onset or familial breast cancer or with ovarian cancer.
0304-3835
Campbell, I.G.
ca276d62-3544-4264-9dd1-3212b1fe4df6
Eccles, D.M.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Choong, D.Y.
ba8c54c0-31d9-4431-87e5-ba5ef5d2ecd2
Campbell, I.G.
ca276d62-3544-4264-9dd1-3212b1fe4df6
Eccles, D.M.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Choong, D.Y.
ba8c54c0-31d9-4431-87e5-ba5ef5d2ecd2

Campbell, I.G., Eccles, D.M. and Choong, D.Y. (2005) No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer. Cancer Letters, 17.

Record type: Article

Abstract

A functional T to G germline polymorphism in the promoter region of MDM2 (SNP309) has been reported to profoundly accelerate tumor formation suggesting that it may also represent a powerful cancer predisposing allele. To investigate the role of SNP309 in cancer predisposition we undertook a case-control study of this polymorphism among 351 women diagnosed with breast cancer, 302 women diagnosed with ovarian and 258 female controls from a British population. The GG genotype was not associated with either breast cancer (OR 1.04, 95% CI 0.67-1.60) or ovarian cancer (OR 0.86, 95% CI 0.53-1.37). This study has found no evidence that the GG genotype of the MDM2 SNP309 polymorphism is associated with early onset or familial breast cancer or with ovarian cancer.

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Published date: 2005

Identifiers

Local EPrints ID: 26234
URI: https://eprints.soton.ac.uk/id/eprint/26234
ISSN: 0304-3835
PURE UUID: 6951366a-ea0f-46be-8a7c-0fbc0d5e0e8e

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Date deposited: 21 Apr 2006
Last modified: 17 Jul 2017 16:08

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