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Apoptosis, ageing and cancer susceptibility

Apoptosis, ageing and cancer susceptibility
Apoptosis, ageing and cancer susceptibility
We have previously shown that peripheral blood lymphocytes (PBL) from individuals carrying a germline TP53 mutation show a dramatically reduced apoptotic response to radiation. As part of a study of this phenomenon, we also investigated apoptotic response in a series of breast cancer patients lacking TP53 mutations and in a control group of individuals without cancer. There was a significant reduction in mean apoptotic response with increasing age in all groups. These findings are consistent with a number of studies in rodents, which have demonstrated a reduction in DNA damage-induced apoptosis with increasing age. In addition, after adjusting for age, breast cancer patients showed significantly reduced apoptotic responses compared with normal controls (P=0.002). The odds ratio for breast cancer in women with an apoptotic response of <35%, compared with women with a response of >49%, was 6.42 (95% CI 1.68-24.6). The data further support the hypothesis that a reduction in apoptotic response to DNA damage with increasing age may play a significant role in the age-related increase in cancer.
apoptosis, radiation, cancer susceptibility, age
0007-0920
487-490
Camplejohn, R.S.
f37de378-9355-4a3b-bacf-6e5e00e6da07
Gilchrist, R.
44635a09-b08c-4ac0-8e0e-99042907959b
Easton, D.
1bccdadd-da65-418d-90ea-483a8fe7dafb
McKenzie-Edwards, E.
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Barnes, D.M.
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Eccles, D.M.
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Ardern-Jones, A.
615ce40c-596a-4b29-9578-13bf644aa3e0
Hodgson, S.V.
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Duddy, P.M.
a55ed30e-914b-4ff0-8e2c-137cb729744c
Eeles, R.A.
b4d711ae-9a55-4557-ad7a-1071488185bb
Camplejohn, R.S.
f37de378-9355-4a3b-bacf-6e5e00e6da07
Gilchrist, R.
44635a09-b08c-4ac0-8e0e-99042907959b
Easton, D.
1bccdadd-da65-418d-90ea-483a8fe7dafb
McKenzie-Edwards, E.
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Barnes, D.M.
d9552c52-d61a-4f7c-a89a-1ff82cfb299a
Eccles, D.M.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Ardern-Jones, A.
615ce40c-596a-4b29-9578-13bf644aa3e0
Hodgson, S.V.
bb6bc7e4-8ddd-4fa3-8ce8-a30cd2a19d94
Duddy, P.M.
a55ed30e-914b-4ff0-8e2c-137cb729744c
Eeles, R.A.
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Camplejohn, R.S., Gilchrist, R., Easton, D., McKenzie-Edwards, E., Barnes, D.M., Eccles, D.M., Ardern-Jones, A., Hodgson, S.V., Duddy, P.M. and Eeles, R.A. (2003) Apoptosis, ageing and cancer susceptibility. British Journal of Cancer, 88 (4), 487-490.

Record type: Article

Abstract

We have previously shown that peripheral blood lymphocytes (PBL) from individuals carrying a germline TP53 mutation show a dramatically reduced apoptotic response to radiation. As part of a study of this phenomenon, we also investigated apoptotic response in a series of breast cancer patients lacking TP53 mutations and in a control group of individuals without cancer. There was a significant reduction in mean apoptotic response with increasing age in all groups. These findings are consistent with a number of studies in rodents, which have demonstrated a reduction in DNA damage-induced apoptosis with increasing age. In addition, after adjusting for age, breast cancer patients showed significantly reduced apoptotic responses compared with normal controls (P=0.002). The odds ratio for breast cancer in women with an apoptotic response of <35%, compared with women with a response of >49%, was 6.42 (95% CI 1.68-24.6). The data further support the hypothesis that a reduction in apoptotic response to DNA damage with increasing age may play a significant role in the age-related increase in cancer.

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More information

Published date: 2003
Keywords: apoptosis, radiation, cancer susceptibility, age

Identifiers

Local EPrints ID: 26235
URI: https://eprints.soton.ac.uk/id/eprint/26235
ISSN: 0007-0920
PURE UUID: 18d70b7b-7fe6-4ad7-b071-577241d62a10

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Date deposited: 19 Apr 2006
Last modified: 26 Oct 2017 10:34

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Contributors

Author: R.S. Camplejohn
Author: R. Gilchrist
Author: D. Easton
Author: E. McKenzie-Edwards
Author: D.M. Barnes
Author: D.M. Eccles
Author: A. Ardern-Jones
Author: S.V. Hodgson
Author: P.M. Duddy
Author: R.A. Eeles

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