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Clinical features, cytogenetics and outcome in acute lymphoblastic and myeloid leukaemia of infancy: report from the MRC Childhood Leukaemia working party

Clinical features, cytogenetics and outcome in acute lymphoblastic and myeloid leukaemia of infancy: report from the MRC Childhood Leukaemia working party
Clinical features, cytogenetics and outcome in acute lymphoblastic and myeloid leukaemia of infancy: report from the MRC Childhood Leukaemia working party
The clinical features, cytogenetics and response to treatment have been examined in 180 infants (aged <1 year) with acute leukaemia; 118 with acute lymphoblastic leukaemia (ALL) and 62 with acute myeloid leukaemia (AML). Comparison of clinical features showed no difference in age or sex distribution between infants with ALL and AML but infants with ALL tended to have higher leucocyte counts at presentation. Cytogenetic abnormalities involving 11q23 were found in 66% of ALL and 35% of AML cases, the commonest, t(4;11) being found only in ALL. The other recognised 11q23 translocations were found in both types of leukaemia. Few patients had the common cytogenetic abnormalities associated with ALL in older children and few with AML had good risk abnormalities. Four year event-free survival 60% cf 30% (P = 0.001) and survival 65% cf 41% (P = 0.007) were significantly better in AML than ALL. These results were due to a lower risk of relapse 27% cf 62% at four years. Superior event-free survival was also seen in the subgroup of patients with 11q23 abnormalities and AML (55% cf 23%). The reasons for superior response in AML are unknown but may be related to the intensity of treatment, lineage of the leukaemia or other as yet unidentified factors.
0887-6924
776-784
Chessells, J.M.
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Harrison, C.J.
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Kempski, H.
f7e3bed4-264e-4cd2-ab47-586a950ce64e
Webb, D.K.
c01d9d60-3eed-4999-9254-878c4b227e8c
Wheatley, K.
ff351180-4419-4585-8bcb-81baff49bfa8
Hann, I.M.
b8b85f3a-b894-45a4-b38a-4b332fe8df30
Stevens, R.F.
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Harrison, G.
4e2c5afa-42b1-48ac-a096-a7729d2ed6da
Gibson, B.E.
c31462a8-e936-4968-a4ba-bdd1a37679f8
Chessells, J.M.
f635630a-7aab-44f8-9e3c-0ee5a07c6b30
Harrison, C.J.
9c9f6b47-8bfc-49dd-b156-74539b170291
Kempski, H.
f7e3bed4-264e-4cd2-ab47-586a950ce64e
Webb, D.K.
c01d9d60-3eed-4999-9254-878c4b227e8c
Wheatley, K.
ff351180-4419-4585-8bcb-81baff49bfa8
Hann, I.M.
b8b85f3a-b894-45a4-b38a-4b332fe8df30
Stevens, R.F.
56316ca6-5b1c-480d-bc1b-1062342109bb
Harrison, G.
4e2c5afa-42b1-48ac-a096-a7729d2ed6da
Gibson, B.E.
c31462a8-e936-4968-a4ba-bdd1a37679f8

Chessells, J.M., Harrison, C.J., Kempski, H., Webb, D.K., Wheatley, K., Hann, I.M., Stevens, R.F., Harrison, G. and Gibson, B.E. (2002) Clinical features, cytogenetics and outcome in acute lymphoblastic and myeloid leukaemia of infancy: report from the MRC Childhood Leukaemia working party. Leukemia, 16 (5), 776-784. (doi:10.1038/sj/leu/2402468).

Record type: Article

Abstract

The clinical features, cytogenetics and response to treatment have been examined in 180 infants (aged <1 year) with acute leukaemia; 118 with acute lymphoblastic leukaemia (ALL) and 62 with acute myeloid leukaemia (AML). Comparison of clinical features showed no difference in age or sex distribution between infants with ALL and AML but infants with ALL tended to have higher leucocyte counts at presentation. Cytogenetic abnormalities involving 11q23 were found in 66% of ALL and 35% of AML cases, the commonest, t(4;11) being found only in ALL. The other recognised 11q23 translocations were found in both types of leukaemia. Few patients had the common cytogenetic abnormalities associated with ALL in older children and few with AML had good risk abnormalities. Four year event-free survival 60% cf 30% (P = 0.001) and survival 65% cf 41% (P = 0.007) were significantly better in AML than ALL. These results were due to a lower risk of relapse 27% cf 62% at four years. Superior event-free survival was also seen in the subgroup of patients with 11q23 abnormalities and AML (55% cf 23%). The reasons for superior response in AML are unknown but may be related to the intensity of treatment, lineage of the leukaemia or other as yet unidentified factors.

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Published date: 2002

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Local EPrints ID: 26244
URI: http://eprints.soton.ac.uk/id/eprint/26244
ISSN: 0887-6924
PURE UUID: e1cb0611-a113-46d2-aa8b-811c9d5057d2

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Date deposited: 12 Apr 2006
Last modified: 17 Jul 2017 16:08

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Author: J.M. Chessells
Author: C.J. Harrison
Author: H. Kempski
Author: D.K. Webb
Author: K. Wheatley
Author: I.M. Hann
Author: R.F. Stevens
Author: G. Harrison
Author: B.E. Gibson

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