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The relevance of sequence insertions in the Mcl-1 promoter in chronic lymphocytic leukemia and in normal cells

The relevance of sequence insertions in the Mcl-1 promoter in chronic lymphocytic leukemia and in normal cells
The relevance of sequence insertions in the Mcl-1 promoter in chronic lymphocytic leukemia and in normal cells
We measured the frequency of insertions in the Mcl-1 promoter in chronic lymphocytic leukemia (CLL) and in normal individuals. Insertions were found in 37/54 (69%) of the CLL samples. However, insertions were not associated with prognostic markers and were also detected in 38/66 (58%) of normal controls and in normal cells isolated from CLL patients. Thus, Mcl-1 insertions are not acquired during leukemogenesis and are unlikely to play an important role in this disease.
0390-6078
1285-1286
Coenen, S.
9afe2a52-9f4f-45bb-b8e5-c6ee3eeb3498
Pickering, B.
9f0b96ba-2d83-45dd-85dc-e257d763f588
Potter, K.N.
86a99047-494b-405b-a3f7-650c1dcd5838
Johnson, P.W.
e01f93bd-4ce9-473a-991c-b770f4a6029b
Stevenson, F.K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Packham, G.
fdabe56f-2c58-469c-aadf-38878f233394
Coenen, S.
9afe2a52-9f4f-45bb-b8e5-c6ee3eeb3498
Pickering, B.
9f0b96ba-2d83-45dd-85dc-e257d763f588
Potter, K.N.
86a99047-494b-405b-a3f7-650c1dcd5838
Johnson, P.W.
e01f93bd-4ce9-473a-991c-b770f4a6029b
Stevenson, F.K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Packham, G.
fdabe56f-2c58-469c-aadf-38878f233394

Coenen, S., Pickering, B., Potter, K.N., Johnson, P.W., Stevenson, F.K. and Packham, G. (2005) The relevance of sequence insertions in the Mcl-1 promoter in chronic lymphocytic leukemia and in normal cells. Haematologica, 90 (9), 1285-1286.

Record type: Article

Abstract

We measured the frequency of insertions in the Mcl-1 promoter in chronic lymphocytic leukemia (CLL) and in normal individuals. Insertions were found in 37/54 (69%) of the CLL samples. However, insertions were not associated with prognostic markers and were also detected in 38/66 (58%) of normal controls and in normal cells isolated from CLL patients. Thus, Mcl-1 insertions are not acquired during leukemogenesis and are unlikely to play an important role in this disease.

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Published date: 2005

Identifiers

Local EPrints ID: 26252
URI: https://eprints.soton.ac.uk/id/eprint/26252
ISSN: 0390-6078
PURE UUID: 0b038f77-e27f-4fbb-a1a8-53112ffa9752
ORCID for F.K. Stevenson: ORCID iD orcid.org/0000-0002-0933-5021
ORCID for G. Packham: ORCID iD orcid.org/0000-0002-9232-5691

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Date deposited: 19 Apr 2006
Last modified: 31 Jan 2019 01:37

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