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Might patients benefit from oral iron therapy following operative treatment of breast carcinoma?

Cutress, R.I., Gupta, R., Parakh, A., Rutter, D., Spencer, L. and Royle, G.T. (2001) Might patients benefit from oral iron therapy following operative treatment of breast carcinoma? European Journal of Surgical Oncology, 27, (7), pp. 621-625. (doi:10.1053/ejso.2001.1205). (PMID:11669588).

Record type: Article


Aims: To assess the changes in blood haemoglobin concentration and serum iron indices as a consequence of breast operations for cancer in our unit.

Methods: Haematological parameters were measured in 109 patients undergoing definitive operative treatment for breast carcinoma.

Results: A mean fall in haemoglobin of 2.1 g (P=0.001) occurred in patients undergoing mastectomy and axillary clearance and of 1.3 g (P<0.001) in patients undergoing wide local excision and axillary clearance. The transferrin saturation (serum iron/total iron binding capacity) in both sets of patients after surgery fell on average to levels that would be expected to impair subsequent red cell production.

Conclusion: The changes in iron indices that occurred were unrelated to the degree of blood loss consistent with a possible inflammatory effect of the operation. Oral iron therapy is unlikely to be of benefit to operative breast patients if they have normal pre-operative iron stores.

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Published date: 2001
Keywords: blood loss, breat cancer, iron, mastectomy


Local EPrints ID: 26266
ISSN: 0748-7983
PURE UUID: 7e60a375-f2ec-4d16-aed8-00a7ecc9fcce

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Date deposited: 21 Apr 2006
Last modified: 17 Jul 2017 16:08

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Author: R.I. Cutress
Author: R. Gupta
Author: A. Parakh
Author: D. Rutter
Author: L. Spencer
Author: G.T. Royle

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