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Might patients benefit from oral iron therapy following operative treatment of breast carcinoma?

Might patients benefit from oral iron therapy following operative treatment of breast carcinoma?
Might patients benefit from oral iron therapy following operative treatment of breast carcinoma?
Aims: To assess the changes in blood haemoglobin concentration and serum iron indices as a consequence of breast operations for cancer in our unit.

Methods: Haematological parameters were measured in 109 patients undergoing definitive operative treatment for breast carcinoma.

Results: A mean fall in haemoglobin of 2.1 g (P=0.001) occurred in patients undergoing mastectomy and axillary clearance and of 1.3 g (P<0.001) in patients undergoing wide local excision and axillary clearance. The transferrin saturation (serum iron/total iron binding capacity) in both sets of patients after surgery fell on average to levels that would be expected to impair subsequent red cell production.

Conclusion: The changes in iron indices that occurred were unrelated to the degree of blood loss consistent with a possible inflammatory effect of the operation. Oral iron therapy is unlikely to be of benefit to operative breast patients if they have normal pre-operative iron stores.
blood loss, breat cancer, iron, mastectomy
0748-7983
621-625
Cutress, R.I.
68ae4f86-e8cf-411f-a335-cdba51797406
Gupta, R.
619ee4fe-3929-46b6-911e-d42188b490f5
Parakh, A.
fcce3389-18b9-4c7c-9197-b25392296e22
Rutter, D.
62b905c7-ac20-4ca1-a7f8-bbc6ebf4282e
Spencer, L.
2ff4c7f9-f529-4bd5-8408-f5a1b892f70b
Royle, G.T.
e69d4bfe-16df-454d-9b69-1230054b8120
Cutress, R.I.
68ae4f86-e8cf-411f-a335-cdba51797406
Gupta, R.
619ee4fe-3929-46b6-911e-d42188b490f5
Parakh, A.
fcce3389-18b9-4c7c-9197-b25392296e22
Rutter, D.
62b905c7-ac20-4ca1-a7f8-bbc6ebf4282e
Spencer, L.
2ff4c7f9-f529-4bd5-8408-f5a1b892f70b
Royle, G.T.
e69d4bfe-16df-454d-9b69-1230054b8120

Cutress, R.I., Gupta, R., Parakh, A., Rutter, D., Spencer, L. and Royle, G.T. (2001) Might patients benefit from oral iron therapy following operative treatment of breast carcinoma? European Journal of Surgical Oncology, 27 (7), 621-625. (doi:10.1053/ejso.2001.1205). (PMID:11669588)

Record type: Article

Abstract

Aims: To assess the changes in blood haemoglobin concentration and serum iron indices as a consequence of breast operations for cancer in our unit.

Methods: Haematological parameters were measured in 109 patients undergoing definitive operative treatment for breast carcinoma.

Results: A mean fall in haemoglobin of 2.1 g (P=0.001) occurred in patients undergoing mastectomy and axillary clearance and of 1.3 g (P<0.001) in patients undergoing wide local excision and axillary clearance. The transferrin saturation (serum iron/total iron binding capacity) in both sets of patients after surgery fell on average to levels that would be expected to impair subsequent red cell production.

Conclusion: The changes in iron indices that occurred were unrelated to the degree of blood loss consistent with a possible inflammatory effect of the operation. Oral iron therapy is unlikely to be of benefit to operative breast patients if they have normal pre-operative iron stores.

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More information

Published date: 2001
Keywords: blood loss, breat cancer, iron, mastectomy

Identifiers

Local EPrints ID: 26266
URI: http://eprints.soton.ac.uk/id/eprint/26266
ISSN: 0748-7983
PURE UUID: 7e60a375-f2ec-4d16-aed8-00a7ecc9fcce

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Date deposited: 21 Apr 2006
Last modified: 15 Mar 2024 07:09

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Contributors

Author: R.I. Cutress
Author: R. Gupta
Author: A. Parakh
Author: D. Rutter
Author: L. Spencer
Author: G.T. Royle

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