BAG-1 expression and function in human cancer

Cutress, R.I., Townsend, P.A., Brimmell, M., Bateman, A.C., Hague, A. and Packham, G. (2002) BAG-1 expression and function in human cancer. British Journal of Cancer, 87 (8), 834-839. (doi:10.1038/sj.bjc.6600538). (PMID:12373595)

Abstract

BAG-1 is a multifunctional protein that interacts with a wide range of target molecules to regulate apoptosis, proliferation, transcription, metastasis and motility. Interaction with chaperone molecules may mediate many of the effects of BAG-1. The pathways regulated by BAG-1 play key roles in the development and progression of cancer and determining response to therapy, and there has been considerable interest in determining the clinical significance of BAG-1 expression in malignant cells. There is an emerging picture that BAG-1 expression is frequently altered in a range of human cancers relative to normal cells and a recent report suggests the exciting possibility that BAG-1 expression may have clinical utility as a prognostic marker in early breast cancer. However, other studies of BAG-1 expression in breast cancer and other cancer types have yielded differing results. It is important to view these findings in the context of current knowledge of BAG-1 expression and function. This review summarises recent progress in understanding the clinical significance of BAG-1 expression in cancer in light of our understanding of BAG-1 function.

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Contributors

Author: G. Packham

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