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BAG-1 expression and function in human cancer

BAG-1 expression and function in human cancer
BAG-1 expression and function in human cancer
BAG-1 is a multifunctional protein that interacts with a wide range of target molecules to regulate apoptosis, proliferation, transcription, metastasis and motility. Interaction with chaperone molecules may mediate many of the effects of BAG-1. The pathways regulated by BAG-1 play key roles in the development and progression of cancer and determining response to therapy, and there has been considerable interest in determining the clinical significance of BAG-1 expression in malignant cells. There is an emerging picture that BAG-1 expression is frequently altered in a range of human cancers relative to normal cells and a recent report suggests the exciting possibility that BAG-1 expression may have clinical utility as a prognostic marker in early breast cancer. However, other studies of BAG-1 expression in breast cancer and other cancer types have yielded differing results. It is important to view these findings in the context of current knowledge of BAG-1 expression and function. This review summarises recent progress in understanding the clinical significance of BAG-1 expression in cancer in light of our understanding of BAG-1 function.
bag-1, heat shock, apoptosis, transcription, cancer
0007-0920
834-839
Cutress, R.I.
68ae4f86-e8cf-411f-a335-cdba51797406
Townsend, P.A.
89300833-c898-4ae1-a3b2-03214c71da52
Brimmell, M.
4bb675a5-c3f0-4ddb-ae49-d39257ba79e1
Bateman, A.C.
4e97a5ca-662c-451d-bdb3-33f35420ceed
Hague, A.
ea2f8822-0c83-4868-a7f0-91e35371e636
Packham, G.
fdabe56f-2c58-469c-aadf-38878f233394
Cutress, R.I.
68ae4f86-e8cf-411f-a335-cdba51797406
Townsend, P.A.
89300833-c898-4ae1-a3b2-03214c71da52
Brimmell, M.
4bb675a5-c3f0-4ddb-ae49-d39257ba79e1
Bateman, A.C.
4e97a5ca-662c-451d-bdb3-33f35420ceed
Hague, A.
ea2f8822-0c83-4868-a7f0-91e35371e636
Packham, G.
fdabe56f-2c58-469c-aadf-38878f233394

Cutress, R.I., Townsend, P.A., Brimmell, M., Bateman, A.C., Hague, A. and Packham, G. (2002) BAG-1 expression and function in human cancer. British Journal of Cancer, 87 (8), 834-839. (doi:10.1038/sj.bjc.6600538). (PMID:12373595)

Record type: Article

Abstract

BAG-1 is a multifunctional protein that interacts with a wide range of target molecules to regulate apoptosis, proliferation, transcription, metastasis and motility. Interaction with chaperone molecules may mediate many of the effects of BAG-1. The pathways regulated by BAG-1 play key roles in the development and progression of cancer and determining response to therapy, and there has been considerable interest in determining the clinical significance of BAG-1 expression in malignant cells. There is an emerging picture that BAG-1 expression is frequently altered in a range of human cancers relative to normal cells and a recent report suggests the exciting possibility that BAG-1 expression may have clinical utility as a prognostic marker in early breast cancer. However, other studies of BAG-1 expression in breast cancer and other cancer types have yielded differing results. It is important to view these findings in the context of current knowledge of BAG-1 expression and function. This review summarises recent progress in understanding the clinical significance of BAG-1 expression in cancer in light of our understanding of BAG-1 function.

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More information

Published date: 2002
Keywords: bag-1, heat shock, apoptosis, transcription, cancer

Identifiers

Local EPrints ID: 26267
URI: http://eprints.soton.ac.uk/id/eprint/26267
ISSN: 0007-0920
PURE UUID: 8471db50-b19f-4f5c-bb35-d756c2031ec0
ORCID for G. Packham: ORCID iD orcid.org/0000-0002-9232-5691

Catalogue record

Date deposited: 21 Apr 2006
Last modified: 19 Nov 2019 01:52

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