Differential regulation of cell survival by CD40
Differential regulation of cell survival by CD40
The CD40 cell surface receptor is required for normal function of the immune system and is a positive regulator of cell survival for normal B-lymphocytes. However, there is evidence to support both pro- and anti-apoptotic functions for CD40 in malignant B-cells and epithelial cancers. There is increasing interest in the potential of CD40 activating agents as novel therapies for cancer and it is essential to understand the differential response of malignant cells, to inform the design of trials. Here we review the current understanding of differential responses to CD40 activation and apoptosis controlling proteins regulated by CD40 that might account for these effects.
apoptosis, cancer, cd40, receptor, therapy
45-53
Dallman, C.
17a87120-84b2-4290-8262-815d8996c3dd
Johnson, P.W.M.
26932758-e8d4-4676-9e55-ed36d00665ea
Packham, G.
fdabe56f-2c58-469c-aadf-38878f233394
2003
Dallman, C.
17a87120-84b2-4290-8262-815d8996c3dd
Johnson, P.W.M.
26932758-e8d4-4676-9e55-ed36d00665ea
Packham, G.
fdabe56f-2c58-469c-aadf-38878f233394
Dallman, C., Johnson, P.W.M. and Packham, G.
(2003)
Differential regulation of cell survival by CD40.
Apoptosis, 8 (1), .
(doi:10.1023/A:1021696902187).
Abstract
The CD40 cell surface receptor is required for normal function of the immune system and is a positive regulator of cell survival for normal B-lymphocytes. However, there is evidence to support both pro- and anti-apoptotic functions for CD40 in malignant B-cells and epithelial cancers. There is increasing interest in the potential of CD40 activating agents as novel therapies for cancer and it is essential to understand the differential response of malignant cells, to inform the design of trials. Here we review the current understanding of differential responses to CD40 activation and apoptosis controlling proteins regulated by CD40 that might account for these effects.
This record has no associated files available for download.
More information
Published date: 2003
Keywords:
apoptosis, cancer, cd40, receptor, therapy
Identifiers
Local EPrints ID: 26271
URI: http://eprints.soton.ac.uk/id/eprint/26271
ISSN: 1360-8185
PURE UUID: 01a3b9de-2341-4d77-8018-3416dd6bf9da
Catalogue record
Date deposited: 21 Apr 2006
Last modified: 16 Mar 2024 03:14
Export record
Altmetrics
Contributors
Author:
C. Dallman
Author:
P.W.M. Johnson
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
