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Differential regulation of cell survival by CD40

Differential regulation of cell survival by CD40
Differential regulation of cell survival by CD40
The CD40 cell surface receptor is required for normal function of the immune system and is a positive regulator of cell survival for normal B-lymphocytes. However, there is evidence to support both pro- and anti-apoptotic functions for CD40 in malignant B-cells and epithelial cancers. There is increasing interest in the potential of CD40 activating agents as novel therapies for cancer and it is essential to understand the differential response of malignant cells, to inform the design of trials. Here we review the current understanding of differential responses to CD40 activation and apoptosis controlling proteins regulated by CD40 that might account for these effects.
apoptosis, cancer, cd40, receptor, therapy
1360-8185
45-53
Dallman, C.
17a87120-84b2-4290-8262-815d8996c3dd
Johnson, P.W.M.
26932758-e8d4-4676-9e55-ed36d00665ea
Packham, G.
fdabe56f-2c58-469c-aadf-38878f233394
Dallman, C.
17a87120-84b2-4290-8262-815d8996c3dd
Johnson, P.W.M.
26932758-e8d4-4676-9e55-ed36d00665ea
Packham, G.
fdabe56f-2c58-469c-aadf-38878f233394

Dallman, C., Johnson, P.W.M. and Packham, G. (2003) Differential regulation of cell survival by CD40. Apoptosis, 8 (1), 45-53. (doi:10.1023/A:1021696902187).

Record type: Article

Abstract

The CD40 cell surface receptor is required for normal function of the immune system and is a positive regulator of cell survival for normal B-lymphocytes. However, there is evidence to support both pro- and anti-apoptotic functions for CD40 in malignant B-cells and epithelial cancers. There is increasing interest in the potential of CD40 activating agents as novel therapies for cancer and it is essential to understand the differential response of malignant cells, to inform the design of trials. Here we review the current understanding of differential responses to CD40 activation and apoptosis controlling proteins regulated by CD40 that might account for these effects.

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More information

Published date: 2003
Keywords: apoptosis, cancer, cd40, receptor, therapy

Identifiers

Local EPrints ID: 26271
URI: https://eprints.soton.ac.uk/id/eprint/26271
ISSN: 1360-8185
PURE UUID: 01a3b9de-2341-4d77-8018-3416dd6bf9da
ORCID for G. Packham: ORCID iD orcid.org/0000-0002-9232-5691

Catalogue record

Date deposited: 21 Apr 2006
Last modified: 31 Jan 2019 01:37

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