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The continued value of central histopathological review of testicular tumours

The continued value of central histopathological review of testicular tumours
The continued value of central histopathological review of testicular tumours
Aims: Central histopathological review of testicular tumours prior to definitive treatment can have an important impact on patient management. This study was designed to assess the continued value of central review in the light of increasing subspecialization and increased numbers of consultant histopathologists.
Materials and results: The original and review reports of 291 testicular cancer specimens from 1998 to 2002 were analysed, looking particularly at major diagnosis, vascular invasion and the tumour elements within non-seminomatous germ cell tumours (NSGCT). When a diagnosis was altered any effect on subsequent patient management was assessed. There was a discrepancy in tumour type in 11 cases (4%) compared with 6% in 1992–1997. The commonest change was from seminoma to NSGCT or combined germ cell tumour (5/11). There was also diagnostic difficulty with spermatocytic seminoma (3/11). The clinical management of all 11 cases was influenced as a result of the review diagnosis. Discrepancies in vascular invasion were noted in 13 of the 126 NSGCTs (10%) compared with 20% in 1992–1997. Differences in NSGCT tumour elements, though clinically less important, were frequent in both groups.
Conclusions: There continues to be a small number of significant and clinically important errors identified following central histopathological review of testicular tumours. This study highlights the value of central review and supports its continued practice in the management of testicular tumours.
1365-2559
166-169
Delaney, R.J.
fd12e8a2-6c4f-46d0-8e03-afc190ea0192
Sayers, C.D.
925e8301-5a7e-47ba-9b70-46be6a6e3ab4
Walker, M.A.
cfc57fa4-f59d-4ae3-8b8a-4bd4a16dc0b8
Mead, G.M.
8a97f978-9c66-4a16-bb03-dd83d20b06a0
Theaker, J.M.
e24ec934-c79c-471c-8556-d38a15ac845b
Delaney, R.J.
fd12e8a2-6c4f-46d0-8e03-afc190ea0192
Sayers, C.D.
925e8301-5a7e-47ba-9b70-46be6a6e3ab4
Walker, M.A.
cfc57fa4-f59d-4ae3-8b8a-4bd4a16dc0b8
Mead, G.M.
8a97f978-9c66-4a16-bb03-dd83d20b06a0
Theaker, J.M.
e24ec934-c79c-471c-8556-d38a15ac845b

Delaney, R.J., Sayers, C.D., Walker, M.A., Mead, G.M. and Theaker, J.M. (2005) The continued value of central histopathological review of testicular tumours. Histopathology, 47 (2), 166-169. (doi:10.1111/j.1365-2559.2005.02207.x).

Record type: Article

Abstract

Aims: Central histopathological review of testicular tumours prior to definitive treatment can have an important impact on patient management. This study was designed to assess the continued value of central review in the light of increasing subspecialization and increased numbers of consultant histopathologists.
Materials and results: The original and review reports of 291 testicular cancer specimens from 1998 to 2002 were analysed, looking particularly at major diagnosis, vascular invasion and the tumour elements within non-seminomatous germ cell tumours (NSGCT). When a diagnosis was altered any effect on subsequent patient management was assessed. There was a discrepancy in tumour type in 11 cases (4%) compared with 6% in 1992–1997. The commonest change was from seminoma to NSGCT or combined germ cell tumour (5/11). There was also diagnostic difficulty with spermatocytic seminoma (3/11). The clinical management of all 11 cases was influenced as a result of the review diagnosis. Discrepancies in vascular invasion were noted in 13 of the 126 NSGCTs (10%) compared with 20% in 1992–1997. Differences in NSGCT tumour elements, though clinically less important, were frequent in both groups.
Conclusions: There continues to be a small number of significant and clinically important errors identified following central histopathological review of testicular tumours. This study highlights the value of central review and supports its continued practice in the management of testicular tumours.

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Submitted date: December 2004
Published date: August 2005

Identifiers

Local EPrints ID: 26277
URI: https://eprints.soton.ac.uk/id/eprint/26277
ISSN: 1365-2559
PURE UUID: aac6af37-c016-4c41-87df-e35c2001d421

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Date deposited: 07 Apr 2006
Last modified: 17 Jul 2017 16:07

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Contributors

Author: R.J. Delaney
Author: C.D. Sayers
Author: M.A. Walker
Author: G.M. Mead
Author: J.M. Theaker

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