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Noise as a Computational Resource

Noise as a Computational Resource
Noise as a Computational Resource
In systems far from equilibrium, such as cellular biomolecular assemblies, energetic input is converted into systematic execution of function. The functional machinery comprises transport and interconversion of matter, as well as signalling systems and the regulation of other functional components. Within the microscopic dimensions of the cell, these processes are carried out by discrete co-ordinated interactions among molecules in a noisy environment. We take the position that given the pronounced effects noise can have in such small volumes having low copy numbers of molecular species, cells have harnessed evolutionary pressures into making productive use of noise. Correspondingly, given the drive towards miniaturisation in future computational hardware, we can view the attendant concerns about “taming” the noise inherent to this regime as an opportunity to learn from the way cells fulfil their transport and information processing needs. In particular, we shall look at how molecular ratchets exploit thermal noise, how signalling processes may exploit fluctuations in the number of enzymes, and how the ability to read out from conformational substates of enzymes can enable targeted low-pass filtering to guide computational steps through a suitably mapped state space.
305-319
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698
Werner, Joern
cd0437ab-64d3-4d8e-ace7-374b48419560
Zauner, Klaus-Peter
c8b22dbd-10e6-43d8-813b-0766f985cc97
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698
Werner, Joern
cd0437ab-64d3-4d8e-ace7-374b48419560
Zauner, Klaus-Peter
c8b22dbd-10e6-43d8-813b-0766f985cc97

Dasmahapatra, Srinandan, Werner, Joern and Zauner, Klaus-Peter (2006) Noise as a Computational Resource. International Journal of Unconventional Computing, Volume (4), 305-319.

Record type: Article

Abstract

In systems far from equilibrium, such as cellular biomolecular assemblies, energetic input is converted into systematic execution of function. The functional machinery comprises transport and interconversion of matter, as well as signalling systems and the regulation of other functional components. Within the microscopic dimensions of the cell, these processes are carried out by discrete co-ordinated interactions among molecules in a noisy environment. We take the position that given the pronounced effects noise can have in such small volumes having low copy numbers of molecular species, cells have harnessed evolutionary pressures into making productive use of noise. Correspondingly, given the drive towards miniaturisation in future computational hardware, we can view the attendant concerns about “taming” the noise inherent to this regime as an opportunity to learn from the way cells fulfil their transport and information processing needs. In particular, we shall look at how molecular ratchets exploit thermal noise, how signalling processes may exploit fluctuations in the number of enzymes, and how the ability to read out from conformational substates of enzymes can enable targeted low-pass filtering to guide computational steps through a suitably mapped state space.

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Published date: December 2006
Organisations: Agents, Interactions & Complexity, Southampton Wireless Group

Identifiers

Local EPrints ID: 263230
URI: https://eprints.soton.ac.uk/id/eprint/263230
PURE UUID: eef4f6f6-a01f-4ffe-ae3f-c12bf0d37613

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Date deposited: 17 Jan 2007
Last modified: 24 Jul 2017 16:41

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Contributors

Author: Joern Werner
Author: Klaus-Peter Zauner

University divisions

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