No association between cytochrome P450 and glutathione S-transferase gene polymorphisms and risk of colorectal adenoma: results from the UK Flexible Sigmoidoscopy Screening Trial

Gunter, Marc J., Watson, Mark A., Loktionov, Alexandre S., Mitrou, Panagiota, Cecil, Tom, Macklin, Christopher, Cardwell, Christopher, Bishop, D. Timothy, Primrose, John, Atkin, Wendy S. and Bingham, Sheila A. (2005) No association between cytochrome P450 and glutathione S-transferase gene polymorphisms and risk of colorectal adenoma: results from the UK Flexible Sigmoidoscopy Screening Trial. Cancer Epidemiology, Biomarkers & Prevention, 14 (4), 1028-1030.

Abstract

INTRODUCTION
Genetic variation in carcinogen metabolizing enzymes has been proposed as a susceptibility marker for colorectal neoplasia. The cytochrome P450 (CYP) and glutathione S-transferase (GST) enzymes metabolize several classes of carcinogen in the human diet and tobacco smoke. Epidemiologic studies that have sought to investigate the relation between variants in CYP and GST genes and colorectal neoplasia have thus far yielded conflicting results and a consensus regarding their etiologic importance has yet to be reached (1). In light of this, we conducted a case-control study, nested within a large randomized controlled trial, to determine whether functionally characterized variants of the CYP1A1, CYP2E1, GSTM1, GSTT1, and GSTM3 genes are associated with risk of colorectal adenoma. In addition, we investigated the interaction between specific dietary components, smoking, genotype, and colorectal adenoma risk.

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Contributors

Author: John Primrose

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