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No association between cytochrome P450 and glutathione S-transferase gene polymorphisms and risk of colorectal adenoma: results from the UK Flexible Sigmoidoscopy Screening Trial

No association between cytochrome P450 and glutathione S-transferase gene polymorphisms and risk of colorectal adenoma: results from the UK Flexible Sigmoidoscopy Screening Trial
No association between cytochrome P450 and glutathione S-transferase gene polymorphisms and risk of colorectal adenoma: results from the UK Flexible Sigmoidoscopy Screening Trial
INTRODUCTION
Genetic variation in carcinogen metabolizing enzymes has been proposed as a susceptibility marker for colorectal neoplasia. The cytochrome P450 (CYP) and glutathione S-transferase (GST) enzymes metabolize several classes of carcinogen in the human diet and tobacco smoke. Epidemiologic studies that have sought to investigate the relation between variants in CYP and GST genes and colorectal neoplasia have thus far yielded conflicting results and a consensus regarding their etiologic importance has yet to be reached (1). In light of this, we conducted a case-control study, nested within a large randomized controlled trial, to determine whether functionally characterized variants of the CYP1A1, CYP2E1, GSTM1, GSTT1, and GSTM3 genes are associated with risk of colorectal adenoma. In addition, we investigated the interaction between specific dietary components, smoking, genotype, and colorectal adenoma risk.
1055-9965
1028-1030
Gunter, Marc J.
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Watson, Mark A.
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Loktionov, Alexandre S.
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Mitrou, Panagiota
ff817936-eda0-4918-b872-f48f6cdbdb6f
Cecil, Tom
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Macklin, Christopher
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Cardwell, Christopher
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Bishop, D. Timothy
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Primrose, John
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Atkin, Wendy S.
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Bingham, Sheila A.
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Gunter, Marc J.
8dde34f9-71b3-4f43-a3bb-f53e0c135154
Watson, Mark A.
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Loktionov, Alexandre S.
bef20815-afc2-4a37-bf24-b435d161552f
Mitrou, Panagiota
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Cecil, Tom
fff8d82e-2019-402f-a931-1c9591ffc133
Macklin, Christopher
f663520b-d069-4cdc-969b-aad147d8473c
Cardwell, Christopher
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Bishop, D. Timothy
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Primrose, John
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Atkin, Wendy S.
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Bingham, Sheila A.
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Gunter, Marc J., Watson, Mark A., Loktionov, Alexandre S., Mitrou, Panagiota, Cecil, Tom, Macklin, Christopher, Cardwell, Christopher, Bishop, D. Timothy, Primrose, John, Atkin, Wendy S. and Bingham, Sheila A. (2005) No association between cytochrome P450 and glutathione S-transferase gene polymorphisms and risk of colorectal adenoma: results from the UK Flexible Sigmoidoscopy Screening Trial. Cancer Epidemiology, Biomarkers & Prevention, 14 (4), 1028-1030.

Record type: Article

Abstract

INTRODUCTION
Genetic variation in carcinogen metabolizing enzymes has been proposed as a susceptibility marker for colorectal neoplasia. The cytochrome P450 (CYP) and glutathione S-transferase (GST) enzymes metabolize several classes of carcinogen in the human diet and tobacco smoke. Epidemiologic studies that have sought to investigate the relation between variants in CYP and GST genes and colorectal neoplasia have thus far yielded conflicting results and a consensus regarding their etiologic importance has yet to be reached (1). In light of this, we conducted a case-control study, nested within a large randomized controlled trial, to determine whether functionally characterized variants of the CYP1A1, CYP2E1, GSTM1, GSTT1, and GSTM3 genes are associated with risk of colorectal adenoma. In addition, we investigated the interaction between specific dietary components, smoking, genotype, and colorectal adenoma risk.

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More information

Published date: 2005
Additional Information: Null results in brief

Identifiers

Local EPrints ID: 26333
URI: http://eprints.soton.ac.uk/id/eprint/26333
ISSN: 1055-9965
PURE UUID: 843364f5-7660-4f0d-8565-45b2bc820d42
ORCID for John Primrose: ORCID iD orcid.org/0000-0002-2069-7605

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Date deposited: 21 Apr 2006
Last modified: 23 Jul 2022 01:38

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Contributors

Author: Marc J. Gunter
Author: Mark A. Watson
Author: Alexandre S. Loktionov
Author: Panagiota Mitrou
Author: Tom Cecil
Author: Christopher Macklin
Author: Christopher Cardwell
Author: D. Timothy Bishop
Author: John Primrose ORCID iD
Author: Wendy S. Atkin
Author: Sheila A. Bingham

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