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Single cell dielectric spectroscopy

Record type: Article

Over the last century a number of techniques have been developed which allow the measurement of the dielectric properties of biological particles in fluid suspension. The majority of these techniques are limited by the fact that they only provide an average value for the dielectric properties of a collection of particles. More recently, with the advent of microfabrication techniques and the Lab-on-a-chip, it has been possible to perform dielectric spectroscopic experiments on single biological particles suspended in physiological media. In this paper we review current methods for single cell dielectric spectroscopy. We also discuss alternative single cell dielectric measurement techniques, specifically the ac electrokinetic methods of dielectrophoresis and electrorotation. Single cell electrical impedance spectroscopy is also discussed with relevance to a microfabricated flow cytometer. We compare impedance spectroscopy data obtained from measurements made using a microfabricated flow cytometer with simulation data obtained using an equivalent circuit model for the device.

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Citation

Morgan, Hywel, Sun, Tao, Holmes, David, Gawad, Shady and Green, Nicolas G (2007) Single cell dielectric spectroscopy Journal of Physics D: Applied Physics, 40, pp. 61-70. (doi:10.1088/0022-3727/40/1/S10).

More information

Published date: January 2007
Organisations: Electronics & Computer Science

Identifiers

Local EPrints ID: 263373
URI: http://eprints.soton.ac.uk/id/eprint/263373
ISSN: 0022-3727
PURE UUID: 87962cf4-d5fd-40d4-9fd4-660ab8991e49
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676
ORCID for Nicolas G Green: ORCID iD orcid.org/0000-0001-9230-4455

Catalogue record

Date deposited: 02 Feb 2007
Last modified: 18 Jul 2017 07:46

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Contributors

Author: Hywel Morgan ORCID iD
Author: Tao Sun
Author: David Holmes
Author: Shady Gawad
Author: Nicolas G Green ORCID iD

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