The University of Southampton
University of Southampton Institutional Repository

Acute lymphoblastic leukaemia

Harrison, Christine J. (2001) Acute lymphoblastic leukaemia Best Practice and Research Clinical Haematology, 14, (3), pp. 593-607. (doi:10.1053/beha.2001.0156).

Record type: Article


In acute lymphoblastic leukaemia (ALL) the karyotype provides important prognostic information which is beginning to have an impact on treatment. The most significant structural chromosomal changes include: the poor-risk abnormalities; t(9;22)(q34;q11), giving rise to the BCR/ABL fusion and rearrangements of theMLL gene; abnormalities previously designated as poor-risk; t(1;19)(q23;p13), producing theE2A/PBX1 and rearrangements of MYC with the immunoglobulin genes; and the probable good risk translocation t(12;21)(p13;q22), which results in the ETV6/AML1 fusion. These abnormalities occur most frequently in B-lineage leukaemias, while rearrangements of the T cell receptor genes are associated with T-lineage ALL. Abnormalities of the short arm of chromosome 9, in particular homozygous deletions involving the tumour suppressor gene (TSG) p16INK4A, are associated with a poor outcome. Numerical chromosomal abnormalities are of particular importance in relation to prognosis. High hyperdiploidy (51–65 chromosomes) is associated with a good risk, whereas the outlook for patients with near haploidy (23–29 chromosomes) is extremely poor. In view of the introduction of risk-adjusted therapy into the UK childhood ALL treatment trials, an interphase FISH screening programme has been developed to reveal chromosomal abnormalities with prognostic significance in childhood ALL. Novel techniques in molecular cytogenetics are identifying new, cryptic abnormalities in small groups of patients which may lead to further improvements in future treatment protocols.

Full text not available from this repository.

More information

Published date: 2001
Keywords: cytogenetics, acute lymphoblastic leukaemia, genetic changes, genes, diagnosis, prognosis, fluorescence in situ hybridization (FISH)


Local EPrints ID: 26366
ISSN: 1521-6926
PURE UUID: 5e6e482b-1660-42f2-a539-d1920a09dcaf

Catalogue record

Date deposited: 24 Apr 2006
Last modified: 17 Jul 2017 16:07

Export record



Author: Christine J. Harrison

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.