The processing of antigens delivered as DNA vaccines

Howarth, M. and Elliott, T. (2004) The processing of antigens delivered as DNA vaccines Immunological Reviews, 199, (1), pp. 27-39. (doi:10.1111/j.0105-2896.2004.00141.x).


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The ability of DNA vaccines to provide effective immunological protection against infection and tumors depends on their ability to generate good CD4+ and CD8+ T-cell responses. Priming of these responses is a property of dendritic cells (DCs), and so the efficacy of DNA-encoded vaccines is likely to depend on the way in which the antigens they encode are processed by DCs. This processing could either be via the synthesis of the vaccine-encoded antigen by the DCs themselves or via its uptake by DCs following its synthesis in bystander cells that are unable to prime T cells. These different sources of antigen are likely to engage different antigen-processing pathways, which are the subject of this review. Understanding how to access different processing pathways in DCs may ultimately aid the rational development of plasmid-based vaccines to pathogens and to cancer.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1111/j.0105-2896.2004.00141.x
ISSNs: 0105-2896 (print)
Related URLs:
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
ePrint ID: 26389
Date :
Date Event
June 2004Published
Date Deposited: 19 Apr 2006
Last Modified: 16 Apr 2017 22:33
Further Information:Google Scholar

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