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The processing of antigens delivered as DNA vaccines

Record type: Article

The ability of DNA vaccines to provide effective immunological protection against infection and tumors depends on their ability to generate good CD4+ and CD8+ T-cell responses. Priming of these responses is a property of dendritic cells (DCs), and so the efficacy of DNA-encoded vaccines is likely to depend on the way in which the antigens they encode are processed by DCs. This processing could either be via the synthesis of the vaccine-encoded antigen by the DCs themselves or via its uptake by DCs following its synthesis in bystander cells that are unable to prime T cells. These different sources of antigen are likely to engage different antigen-processing pathways, which are the subject of this review. Understanding how to access different processing pathways in DCs may ultimately aid the rational development of plasmid-based vaccines to pathogens and to cancer.

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Citation

Howarth, M. and Elliott, T. (2004) The processing of antigens delivered as DNA vaccines Immunological Reviews, 199, (1), pp. 27-39. (doi:10.1111/j.0105-2896.2004.00141.x).

More information

Published date: June 2004

Identifiers

Local EPrints ID: 26389
URI: http://eprints.soton.ac.uk/id/eprint/26389
ISSN: 0105-2896
PURE UUID: 9bc8010d-ae00-431b-bb7c-9d9763ea193e
ORCID for T. Elliott: ORCID iD orcid.org/0000-0003-1097-0222

Catalogue record

Date deposited: 19 Apr 2006
Last modified: 17 Jul 2017 16:07

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