The processing of antigens delivered as DNA vaccines
Howarth, M. and Elliott, T. (2004) The processing of antigens delivered as DNA vaccines Immunological Reviews, 199, (1), pp. 27-39. (doi:10.1111/j.0105-2896.2004.00141.x).
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The ability of DNA vaccines to provide effective immunological protection against infection and tumors depends on their ability to generate good CD4+ and CD8+ T-cell responses. Priming of these responses is a property of dendritic cells (DCs), and so the efficacy of DNA-encoded vaccines is likely to depend on the way in which the antigens they encode are processed by DCs. This processing could either be via the synthesis of the vaccine-encoded antigen by the DCs themselves or via its uptake by DCs following its synthesis in bystander cells that are unable to prime T cells. These different sources of antigen are likely to engage different antigen-processing pathways, which are the subject of this review. Understanding how to access different processing pathways in DCs may ultimately aid the rational development of plasmid-based vaccines to pathogens and to cancer.
|Digital Object Identifier (DOI):||doi:10.1111/j.0105-2896.2004.00141.x|
|Subjects:||R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)|
|Date Deposited:||19 Apr 2006|
|Last Modified:||18 Feb 2017 16:37|
Funded by: MRC (UNSPECIFIED)
UNSPECIFIED to UNSPECIFIED
|Further Information:||Google Scholar|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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