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A randomized trial of amifostine as a cytoprotective agent in patients receiving chemotherapy for small cell lung cancer

Johnson, P.W.M., Muers, M.F., Peake, M.D., Poulter, K.M., Gurney, E.M., Napp, V.V., Hepburn, P.M. and Brown, J.M. (2001) A randomized trial of amifostine as a cytoprotective agent in patients receiving chemotherapy for small cell lung cancer British Journal of Cancer, 84, (1), pp. 19-24. (doi:10.1054/bjoc.2000.1539).

Record type: Article

Abstract

A randomized trial was conducted to determine whether administration of Amifostine with chemotherapy for small cell lung cancer could decrease the toxicity. 84 patients with small cell lung cancer of favourable prognosis (limited disease, performance status 0-1; limited disease with performance status 2 but normal sodium and alkaline phosphatase, or extensive diseas with performance status 0-1, normal sodium and alkaline phosphatase) received treatment with Ifosfamide 3 g/m2intravenously, Carboplatin (Glomerular filtration rate + 25) ´6 mg intravenously, Etoposide 50 mg orally, twice daily, for 7 days, every 3 weeks. Patients were randomized to receive amifostine 740 mg/m2immediately prior to the intravenous drugs (n = 42) or to receive chemotherapy alone (n = 42). The two groups were similar with respect to baseline prognostic factors. There was no significant difference in the occurrence of grade III or IV neutropenia or thrombocytopenia between the two groups, nor in the response rate or overall survival, for which the median was 11 months in the chemotherapy only group and 14 months in the group treated with amifostine. This study has not shown a protective effect from the use of amifostine with this regimen and there does not appear to be any effect upon the efficacy of treatment.

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More information

Published date: 2001
Keywords: small cell lung cancer, chemotherapy, myelotoxicity, chemoprotection, amifostine, survival

Identifiers

Local EPrints ID: 26413
URI: http://eprints.soton.ac.uk/id/eprint/26413
ISSN: 0007-0920
PURE UUID: d04e79c7-3fb4-43db-95f4-b65637123db2

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Date deposited: 24 Apr 2006
Last modified: 17 Jul 2017 16:07

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Contributors

Author: P.W.M. Johnson
Author: M.F. Muers
Author: M.D. Peake
Author: K.M. Poulter
Author: E.M. Gurney
Author: V.V. Napp
Author: P.M. Hepburn
Author: J.M. Brown

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