Immunoglobulin M myeloma: evaluation of molecular features and cytokine expression
Immunoglobulin M myeloma: evaluation of molecular features and cytokine expression
Immunoglobulin (Ig) M myeloma is a distinct entity with features of multiple myeloma (MM) and Waldenström’s macroglobulinemia (WM). The malignant cells in IgM myeloma have a distinctive chromosomal translocation that differentiates them from WM. These cells are postgerminal–center in origin with isotype-switch transcripts. They appear to be arrested at a point of maturation between that of WM and MM. Preliminary data indicate that a pattern of osteoclast-activating factor and osteoprotegerin expression similar to that observed in classic MM is present in IgM myeloma. Additional studies on patients with this rare tumor may provide further insight into the pathogenesis of bone disease in plasma cell dyscrasias.
285-289
Konduri, K.
e145ed7c-9345-4edd-b639-6b411b15e5b0
Sahota, S.S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Babbage, G.
d2036377-f36a-4a4a-8634-4b0394dffe28
Tong, A.W.
4643f4d0-4d25-48e8-94bc-c5a9641a8bb9
Kumar, P.
f57e4ef2-18e6-4f90-be71-7450c42df258
Newman, J.T.
8784a2cd-8547-4146-a27e-846c931ef4e6
Stone, M.J.
021ec46d-7733-4b54-9291-77de609a3ead
2005
Konduri, K.
e145ed7c-9345-4edd-b639-6b411b15e5b0
Sahota, S.S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Babbage, G.
d2036377-f36a-4a4a-8634-4b0394dffe28
Tong, A.W.
4643f4d0-4d25-48e8-94bc-c5a9641a8bb9
Kumar, P.
f57e4ef2-18e6-4f90-be71-7450c42df258
Newman, J.T.
8784a2cd-8547-4146-a27e-846c931ef4e6
Stone, M.J.
021ec46d-7733-4b54-9291-77de609a3ead
Konduri, K., Sahota, S.S., Babbage, G., Tong, A.W., Kumar, P., Newman, J.T. and Stone, M.J.
(2005)
Immunoglobulin M myeloma: evaluation of molecular features and cytokine expression.
Clinical Lymphoma, 5 (4), .
Abstract
Immunoglobulin (Ig) M myeloma is a distinct entity with features of multiple myeloma (MM) and Waldenström’s macroglobulinemia (WM). The malignant cells in IgM myeloma have a distinctive chromosomal translocation that differentiates them from WM. These cells are postgerminal–center in origin with isotype-switch transcripts. They appear to be arrested at a point of maturation between that of WM and MM. Preliminary data indicate that a pattern of osteoclast-activating factor and osteoprotegerin expression similar to that observed in classic MM is present in IgM myeloma. Additional studies on patients with this rare tumor may provide further insight into the pathogenesis of bone disease in plasma cell dyscrasias.
This record has no associated files available for download.
More information
Published date: 2005
Additional Information:
Case Report
Identifiers
Local EPrints ID: 26428
URI: http://eprints.soton.ac.uk/id/eprint/26428
ISSN: 1526-9655
PURE UUID: d6776a12-1215-477f-8834-25f639f923c8
Catalogue record
Date deposited: 10 Apr 2006
Last modified: 22 Jul 2022 20:34
Export record
Contributors
Author:
K. Konduri
Author:
S.S. Sahota
Author:
G. Babbage
Author:
A.W. Tong
Author:
P. Kumar
Author:
J.T. Newman
Author:
M.J. Stone
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics