The University of Southampton
University of Southampton Institutional Repository

Immunoglobulin M myeloma: evaluation of molecular features and cytokine expression

Immunoglobulin M myeloma: evaluation of molecular features and cytokine expression
Immunoglobulin M myeloma: evaluation of molecular features and cytokine expression
Immunoglobulin (Ig) M myeloma is a distinct entity with features of multiple myeloma (MM) and Waldenström’s macroglobulinemia (WM). The malignant cells in IgM myeloma have a distinctive chromosomal translocation that differentiates them from WM. These cells are postgerminal–center in origin with isotype-switch transcripts. They appear to be arrested at a point of maturation between that of WM and MM. Preliminary data indicate that a pattern of osteoclast-activating factor and osteoprotegerin expression similar to that observed in classic MM is present in IgM myeloma. Additional studies on patients with this rare tumor may provide further insight into the pathogenesis of bone disease in plasma cell dyscrasias.
1526-9655
285-289
Konduri, K.
e145ed7c-9345-4edd-b639-6b411b15e5b0
Sahota, S.S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Babbage, G.
d2036377-f36a-4a4a-8634-4b0394dffe28
Tong, A.W.
4643f4d0-4d25-48e8-94bc-c5a9641a8bb9
Kumar, P.
f57e4ef2-18e6-4f90-be71-7450c42df258
Newman, J.T.
8784a2cd-8547-4146-a27e-846c931ef4e6
Stone, M.J.
021ec46d-7733-4b54-9291-77de609a3ead
Konduri, K.
e145ed7c-9345-4edd-b639-6b411b15e5b0
Sahota, S.S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Babbage, G.
d2036377-f36a-4a4a-8634-4b0394dffe28
Tong, A.W.
4643f4d0-4d25-48e8-94bc-c5a9641a8bb9
Kumar, P.
f57e4ef2-18e6-4f90-be71-7450c42df258
Newman, J.T.
8784a2cd-8547-4146-a27e-846c931ef4e6
Stone, M.J.
021ec46d-7733-4b54-9291-77de609a3ead

Konduri, K., Sahota, S.S., Babbage, G., Tong, A.W., Kumar, P., Newman, J.T. and Stone, M.J. (2005) Immunoglobulin M myeloma: evaluation of molecular features and cytokine expression. Clinical Lymphoma, 5 (4), 285-289.

Record type: Article

Abstract

Immunoglobulin (Ig) M myeloma is a distinct entity with features of multiple myeloma (MM) and Waldenström’s macroglobulinemia (WM). The malignant cells in IgM myeloma have a distinctive chromosomal translocation that differentiates them from WM. These cells are postgerminal–center in origin with isotype-switch transcripts. They appear to be arrested at a point of maturation between that of WM and MM. Preliminary data indicate that a pattern of osteoclast-activating factor and osteoprotegerin expression similar to that observed in classic MM is present in IgM myeloma. Additional studies on patients with this rare tumor may provide further insight into the pathogenesis of bone disease in plasma cell dyscrasias.

This record has no associated files available for download.

More information

Published date: 2005
Additional Information: Case Report

Identifiers

Local EPrints ID: 26428
URI: http://eprints.soton.ac.uk/id/eprint/26428
ISSN: 1526-9655
PURE UUID: d6776a12-1215-477f-8834-25f639f923c8

Catalogue record

Date deposited: 10 Apr 2006
Last modified: 22 Jul 2022 20:34

Export record

Contributors

Author: K. Konduri
Author: S.S. Sahota
Author: G. Babbage
Author: A.W. Tong
Author: P. Kumar
Author: J.T. Newman
Author: M.J. Stone

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×