Nucleic Acid Enzymes: The Fusion of Self-assembly and Conformational Computing

(2007) Nucleic Acid Enzymes: The Fusion of Self-assembly and Conformational Computing In, Unconventional Computing 2007. Luniver Press pp. 63-94.

WarningThere is a more recent version of this item available.


Download (581kB)
[img] Indexer Terms UNSPECIFIED
Download (15kB)


Abstract. Macromolecules are the predominant physical substrate supporting information processing in organisms. Two key characteristics—--conformational dynamics and self-assembly properties—--render macromolecules unique in this context. Both characteristics have been investi- gated for technical applications. In nature’s information processors self- assembly and conformational switching commonly appear in combination and are typically realised with proteins. At the current state of biotechnology the best candidates for implementing arti?cal molecular informa- tion processing systems that utilise the combination self-assembly and conformational switching are functional nucleic acids. The increasingly realised prevalence of oligonucleotides in intracellular control points towards potential applications. The present paper reviews approaches to integrating the self-assembly and the conformational paradigm with allosterically controlled nucleic acid enzymes. It also introduces a new computational work?ow to design functional nucleic acids for information processing.

Item Type: Book Section
ePrint ID: 264345
Date Deposited: 26 Jul 2007
Last Modified: 31 Mar 2016 14:09
Further Information:Google Scholar

Available Versions of this Item

Actions (login required)

View Item View Item